Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Rabbit anti-Mouse PR Domain Containing Protein 1 (PRDM1) Polyclonal Antibody | anti-PRDM1 antibody
Polyclonal Antibody to PR Domain Containing Protein 1 (PRDM1)
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF-NVCAK TFGQLSNLKV HLRVHSGERP FKCQTCNKGF TQLAHLQKHY LVHTGEKPHE CQVCHKRFSS TSNLKTHLRL HSGEKPYQCK VCPAKFTQFV HLKLHKRLHT RERPHKCAQC HKSYIHLCSL KVHLKGNCPA GPAAGLPLED LTRINEEIER FDISDNADRL EDMEDSVDVT SMVEKEILAV VRKEKEETSL KVSLQRNMGN GLLSSGCSLY ESSDLSLMKL PHSNPLPLVP VKV
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DABstainingonIHC-P.Samples:MouseTissue))
Immunohistochemistry (IHC)
(DABstainingonIHC-P.Samples:MouseTissue))
NCBI and Uniprot Product Information
Uniprot Description
PRDM1: a transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene and can inhibit virus-mediated IFN-¿ production. Recruits chromatin-modifying enzymes including histone deacetylases and methyltransferases. Drives the maturation of B-lymphocytes into Ig secreting cells. Interacts with PRMT5. Expression of Blimp-1 is sufficient to drive terminal differentiation of BCL1 lymphoma cells into antibody secreting plasma cells, increasing the expression of the cell surface marker Syndecan-1. In the B-cell lineage, Blimp-1 is specifically expressed in antibody-secreting cells including activated B and plasma cells. In addition, Blimp-1 has been found during macrophage differentiation and in a subset of T-cells suggesting that it may play a wider role in homeostasis and differentiation. Target genes of Blimp-1 transcriptional repression with potential roles in differentiation include c-Myc, CIITA, Pax5, Spi-B, and Id3.Three isoforms of the human protein are produced by alternative splicing.
Protein type: C2H2-type zinc finger protein; DNA-binding; Methyltransferase, protein lysine, predicted; Transcription regulation; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 10 B2|10 23.24 cM
Cellular Component: cytoplasm; nucleus
Molecular Function: DNA binding; histone deacetylase binding; metal ion binding; methyltransferase activity; nucleic acid binding; promoter-specific chromatin binding; protein binding; sequence-specific DNA binding; transferase activity
Biological Process: adaptive immune response; artery morphogenesis; cardiac septum development; cell fate commitment; embryonic placenta development; eye photoreceptor cell development; germ cell development; heart valve development; immune system process; in utero embryonic development; innate immune response; maternal placenta development; methylation; morphogenesis of a branching structure; multicellular organism development; negative regulation of B cell proliferation; negative regulation of gene expression; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of transcription from RNA polymerase II promoter; positive regulation of B cell differentiation; positive regulation of gene expression; post-embryonic development; regulation of cell proliferation; regulation of extrathymic T cell differentiation; regulation of natural killer cell differentiation; regulation of NK T cell differentiation; regulation of transcription, DNA-templated; sebum secreting cell proliferation; transcription, DNA-dependent; ventricular septum development
Research Articles on PRDM1
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Product Notes
The PRDM1 prdm1 (Catalog #AAA2004419) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to PR Domain Containing Protein 1 (PRDM1) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's PR Domain Containing Protein 1 (PRDM1) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the PRDM1 prdm1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below. MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF-NVC AK TFGQLSNLKV HLRVHSGERP FKCQTCNKGF TQLAHLQKHY LVHTGEKPHE CQVCHKRFSS TSNLKTHLRL HSGEKPYQCK VCPAKFTQFV HLKLHKRLHT RERPHKCAQC HKSYIHLCSL KVHLKGNCPA GPAAGLPLED LTRINEEIER FDISDNADRL EDMEDSVDVT SMVEKEILAV VRKEKEETSL KVSLQRNMGN GLLSSGCSLY ESSDLSLMKL PHSNPLPLVP VKV. It is sometimes possible for the material contained within the vial of "PR Domain Containing Protein 1 (PRDM1), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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