Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Rabbit anti-Human Secreted Ly6/uPAR Related Protein 1 (SLURP1) Polyclonal Antibody | anti-SLURP1 antibody
Polyclonal Antibody to Secreted Ly6/uPAR Related Protein 1 (SLURP1)
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF-MASRWAVQLL LVAAWSMGCG EALKCYTCKE PMTSASCRTI TRCKPEDTAC MTTLVTVEAE YPFNQSPVVT RSCSSSCVAT DPDSIGAAHL IFCCFRDLCN SEL
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin- embedded breast cancer tissue))
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin- embedded breast cancer tissue))
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Colorectal cancer Tissue))
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Colorectal cancer Tissue))
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors. [provided by RefSeq, Jul 2008]
Uniprot Description
SLURP1: Has an antitumor activity. Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin. Defects in SLURP1 are a cause of Mal de Meleda (MDM); also known as keratosis palmoplantaris transgradiens of Siemens. MDM is a rare autosomal recessive skin disorder, characterized by diffuse transgressive palmoplantar keratoderma with keratotic lesions extending onto the dorsa of the hands and the feet (transgrediens). Patients may have hyperhidrosis. Other features include perioral erythema, lichenoid plaques on the knees and the elbows, and nail abnormalities.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 8q24.3
Cellular Component: extracellular region; extracellular space
Molecular Function: acetylcholine receptor activator activity; cytokine activity
Biological Process: cell activation; cell adhesion; locomotory behavior; negative regulation of cell migration; negative regulation of cell proliferation; neuromuscular process controlling posture
Disease: Mal De Meleda
Research Articles on SLURP1
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Product Notes
The SLURP1 slurp1 (Catalog #AAA2002526) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Secreted Ly6/uPAR Related Protein 1 (SLURP1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Secreted Ly6/uPAR Related Protein 1 (SLURP1) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the SLURP1 slurp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below. MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF-MAS RWAVQLL LVAAWSMGCG EALKCYTCKE PMTSASCRTI TRCKPEDTAC MTTLVTVEAE YPFNQSPVVT RSCSSSCVAT DPDSIGAAHL IFCCFRDLCN SEL. It is sometimes possible for the material contained within the vial of "Secreted Ly6/uPAR Related Protein 1 (SLURP1), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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