Western Blot (WB)
(Western Blot: Sample: Lane1: Mouse Lung Tissue; Lane2: Mouse Liver Tissue.)
Rabbit anti-Mouse Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) Polyclonal Antibody | anti-CYR61 antibody
Polyclonal Antibody to Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61)
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF-DDLLG LDASEVELTR NNELIAIGKG SSLKRLPVFG TEPRVLFNPL HAHGQKCIVQ TTSWSQCSKS CGTGISTRVT NDNPECRLVK ETRICEVRPC GQPVYSSLKK GKKCSKTKKS PEPVRFTYAG CSSVKKYRPK YCGSCVDGRC CTPLQTRTVK MRFRCEDGEM FSKNVMMIQS CKCNYNCPHP NEASFRLYSL FNDIHKFRD
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Lane1: Mouse Lung Tissue; Lane2: Mouse Liver Tissue.)
Western Blot (WB)
(Western Blot: Sample: Lane1: Mouse Lung Tissue; Lane2: Mouse Liver Tissue.)
Western Blot (WB)
(Western Blot: Sample: Recombinant CYR61, Mouse.)
Western Blot (WB)
(Western Blot: Sample: Recombinant CYR61, Mouse.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Stomach Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Stomach Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Intestine Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Intestine Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Kidney Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Kidney Tissue)
NCBI and Uniprot Product Information
Uniprot Description
CYR61: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. Belongs to the CCN family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 3 H2|3 70.18 cM
Cellular Component: extracellular matrix; extracellular region; extracellular space; proteinaceous extracellular matrix
Molecular Function: extracellular matrix binding; growth factor binding; heparin binding; insulin-like growth factor binding; integrin binding
Biological Process: cell adhesion; cell-cell signaling; chemotaxis; extracellular matrix organization; intussusceptive angiogenesis; negative regulation of apoptosis; osteoblast differentiation; positive regulation of apoptosis; positive regulation of BMP signaling pathway; positive regulation of cell differentiation; positive regulation of cell migration; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of osteoblast differentiation; positive regulation of osteoblast proliferation; positive regulation of protein kinase activity; positive regulation of protein phosphorylation; positive regulation of transcription from RNA polymerase II promoter; regulation of cell growth; signal transduction
Research Articles on CYR61
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Product Notes
The CYR61 cyr61 (Catalog #AAA2002418) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the CYR61 cyr61 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below. MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF-DDL LG LDASEVELTR NNELIAIGKG SSLKRLPVFG TEPRVLFNPL HAHGQKCIVQ TTSWSQCSKS CGTGISTRVT NDNPECRLVK ETRICEVRPC GQPVYSSLKK GKKCSKTKKS PEPVRFTYAG CSSVKKYRPK YCGSCVDGRC CTPLQTRTVK MRFRCEDGEM FSKNVMMIQS CKCNYNCPHP NEASFRLYSL FNDIHKFRD. It is sometimes possible for the material contained within the vial of "Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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