Rat Transforming Growth Factor Beta 3 (TGFb3) CLIA Kit | TGFb3 clia kit

Rat Transforming Growth Factor Beta 3 (TGFb3) CLIA Kit

Cat. Num. AAA2001154

• Gene Names: TGFB3; ARVD; RNHF; ARVD1; TGF-beta3
• Reactivity: Rat
• Synonyms: Transforming Growth Factor Beta 3 (TGFb3); Rat Transforming Growth Factor Beta 3 (TGFb3) CLIA Kit; TGF-B3; LAP; Latency-associated peptide; TGFb3 clia kit

• Reactivity: Rat
• Specificity: This assay has high sensitivity and excellent specificity for detection of Transforming Growth Factor Beta 3 (TGFb3).; No significant cross-reactivity or interference between Transforming Growth Factor Beta 3 (TGFb3) and analogues was observed.
• Sequence Length: 52

• Assay Type: Double-antibody Sandwich
• Samples: Serum, Plasma and Other Biological Fluids
• Detection Range: 1.37-1,000pg/mL
• Sensitivity: < 0.62pg/mL
• Application: Chemiluminescent immunoassay for Antigen Detection.
• Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Transforming Growth Factor Beta 3 (TGFb3) were tested 20 times on one plate, respectively.
• Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Transforming Growth Factor Beta 3 (TGFb3) were tested on 3 different plates, 8 replicates in each plate.
• CV(%) =: SD/meanX100
• Intra-Assay: CV<10%
• Inter-Assay: CV<12%
• Preparation and Storage: The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition. ; To minimize extra influence on the performance, operation procedures and lab conditions, especially room temperature, air humidity, incubator temperature should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same operator from the beginning to the end.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for TGFb3 clia kit

The microplate provided in this kit has been pre-coated with an antibody specific to Transforming Growth Factor Beta 3 (TGFb3). Standards or samples are then added to the appropriate microplate wells with a biotin-conjugated antibody specific to Transforming Growth Factor Beta 3 (TGFb3). Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then the mixture of substrate A and B is added to generate glow light emission kinetics. Upon plate development, the intensity of the emitted light is proportional to the Transforming Growth Factor Beta 3 (TGFb3) level in the sample or standard.;

Product Categories/Family for TGFb3 clia kit

Cytokine; Tumor immunity; Infection immunity

NCBI and Uniprot Product Information

• NCBI GI #: 37683095
• NCBI GeneID: 7043
• UniProt Accession #: P10600; Q8WV88
• Molecular Weight: 35,708 Da
• NCBI Official Full Name: transforming growth factor beta 3, partial
• NCBI Official Synonym Full Names: transforming growth factor, beta 3
• NCBI Official Symbol: TGFB3
• NCBI Official Synonym Symbols: ARVD; RNHF; ARVD1; TGF-beta3
• NCBI Protein Information: transforming growth factor beta-3
• UniProt Protein Name: Transforming growth factor beta-3
• Protein Family: Transforming growth factor
• UniProt Gene Name: TGFB3
• UniProt Synonym Gene Names: TGF-beta-3; LAP
• UniProt Entry Name: TGFB3_HUMAN

NCBI Description

This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Mar 2009]

Uniprot Description

TGFB3: Involved in embryogenesis and cell differentiation. Homodimer; disulfide-linked. Interacts with ASPN. Belongs to the TGF-beta family.

Protein type: Ligand, receptor tyrosine kinase; Secreted; Secreted, signal peptide; Cell development/differentiation; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 14q24

Cellular Component: extracellular matrix; extracellular space; cell surface; cell soma; T-tubule; plasma membrane; extracellular region; nucleus

Molecular Function: identical protein binding; protein binding; growth factor activity; transforming growth factor beta binding; protein heterodimerization activity; punt binding; cytokine activity

Biological Process: extracellular matrix organization and biogenesis; positive regulation of apoptosis; activation of MAPK activity; positive regulation of transcription, DNA-dependent; positive regulation of collagen biosynthetic process; SMAD protein nuclear translocation; palate development; female pregnancy; regulation of apoptosis; odontogenesis; negative regulation of cell proliferation; platelet degranulation; mammary gland development; transforming growth factor beta receptor signaling pathway; salivary gland morphogenesis; embryonic neurocranium morphogenesis; negative regulation of neuron apoptosis; cell growth; inner ear development; aging; positive regulation of filopodium formation; uterine wall breakdown; platelet activation; intercellular junction assembly and maintenance; in utero embryonic development; positive regulation of bone mineralization; regulation of cell proliferation; positive regulation of protein secretion; gut development; response to estrogen stimulus; negative regulation of DNA replication; regulation of MAPKKK cascade; positive regulation of cell division; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; response to progesterone stimulus; blood coagulation; alveolus development; positive regulation of DNA replication

Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 1; Rienhoff Syndrome