Parathyroid Hormone (rHuPTH) Active Protein | rHuPTH active protein
Recombinant Human Parathyroid Hormone (rHuPTH)
Gene Names
PTH; PTH1
Purity
>98% as determined by RP-HPLC and SDS-PAGE.
Synonyms
Parathyroid Hormone (rHuPTH); Recombinant Human Parathyroid Hormone (rHuPTH); Human Parathyroid Hormone (rHuPTH); rHuPTH active protein
Purity/Purification
>98% as determined by RP-HPLC and SDS-PAGE.
Form/Format
(1 mg/ml) was lyophilized after extensive dialysis against 1.15mg sodium citrate, 7.31mg sodium chloride, 0.21 mg citric acid, 0.1117mg EDTA-Na2, 0.2mg Tween 80 and 50mg mannitol.
Sequence
Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-GluTrp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe.
Sequence Length
115
Biological Activity
Specific activity of 10,000 Units/mg as determined by the UMR106 cell/cAMP method.
Reconstitution
Reconstitute lyophilized rHuPTH in sterile distilled H2O to not less than 100ug/ml which can then be further diluted in other aqueous solutions.
Preparation and Storage
Lyophilized rHuPTH should be stored desiccated below-20 degree C.
Upon reconstitution, rHuPTH may be stored at 4 degree C for 2-7 days and, for future use, below-20 degree C.
For long term storage it is recommended that a carrier protein (0.1% HSA or BSA) is added.
Prepare appropriate aliquots to avoid multiple freeze-thaw cycles.
Upon reconstitution, rHuPTH may be stored at 4 degree C for 2-7 days and, for future use, below-20 degree C.
For long term storage it is recommended that a carrier protein (0.1% HSA or BSA) is added.
Prepare appropriate aliquots to avoid multiple freeze-thaw cycles.
Related Product Information for rHuPTH active protein
Description: Recombinant Human Parathyroid Hormone (C181H290N55O51S2) is produced in E Coli as a single, non-glycosylated, polypeptide chain containing 34 amino acids and having a molecular mass of 4117.8 Dalton and is purified by proprietary chromatographic techniques.
Backgound: Parathyroid hormone (PTH) is a 84-amino acid polypeptide secreted by parathyroid glands that increases the concentration of calcium in the blood through its interaction with parathyroid hormone receptors in bones, kidney, and intestines. In bones PTH enhances the release of calcium from the large reservoir contained in bones, in kidney it enhances active reabsorption of calcium from distal tubules and the thick ascending limb, and in intestines it enhances the absorption of calcium by increasing the production of vitamin D and upregulating the enzyme responsible for 1-alpha hydroxylation of 25-hydroxy vitamin D, converting vitamin D to its active form (1,25-dihydroxy vitamin D) which effects the absorption of calcium (as Ca2+ ions) by the intestine via calbindin.
Backgound: Parathyroid hormone (PTH) is a 84-amino acid polypeptide secreted by parathyroid glands that increases the concentration of calcium in the blood through its interaction with parathyroid hormone receptors in bones, kidney, and intestines. In bones PTH enhances the release of calcium from the large reservoir contained in bones, in kidney it enhances active reabsorption of calcium from distal tubules and the thick ascending limb, and in intestines it enhances the absorption of calcium by increasing the production of vitamin D and upregulating the enzyme responsible for 1-alpha hydroxylation of 25-hydroxy vitamin D, converting vitamin D to its active form (1,25-dihydroxy vitamin D) which effects the absorption of calcium (as Ca2+ ions) by the intestine via calbindin.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
12,861 Da
NCBI Official Full Name
parathyroid hormone isoform 1 preproprotein
NCBI Official Synonym Full Names
parathyroid hormone
NCBI Official Symbol
PTH
NCBI Official Synonym Symbols
PTH1
NCBI Protein Information
parathyroid hormone
UniProt Protein Name
Parathyroid hormone
UniProt Gene Name
PTH
UniProt Synonym Gene Names
PTH
NCBI Description
This gene encodes a member of the parathyroid family of proteins. The encoded preproprotein is proteolytically processed to generate a protein that binds to the parathyroid hormone/parathyroid hormone-related peptide receptor and regulates blood calcium and phosphate levels. Excess production of the encoded protein, known as hyperparathyroidism, can result in hypercalcemia and kidney stones. On the other hand, defective processing of the encoded protein may lead to hypoparathyroidism, which can result in hypocalcemia and numbness. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Uniprot Description
PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.
Research Articles on rHuPTH
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Product Notes
The rHuPTH pth (Catalog #AAA191508) is an Active Protein and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Ser-Val-Se r-Glu-Ile- Gln-Leu-Me t-His-Asn- Leu-Gly-Ly s-His-Leu- Asn-Ser-Me t-Glu-Arg- Val-GluTrp -Leu-Arg-L ys-Lys-Leu -Gln-Asp-V al-His-Asn -Phe. It is sometimes possible for the material contained within the vial of "Parathyroid Hormone (rHuPTH), Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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