Mouse anti-Human Tomm34 Monoclonal Antibody | anti-Tomm34 antibody

Anti-Hu Tomm34 Purified

Cat. Num. AAA1801831

• Gene Names: TOMM34; TOM34; URCC3; HTOM34P
• Reactivity: Human
• Applications: Western Blot, Immunocytochemistry, Immunoprecipitation
• Purity: Purified by protein-A affinity chromatography
• Synonyms: Tomm34; Monoclonal Antibody; Anti-Hu Tomm34 Purified; URCC3; HTOM34P; Translocase of outer mitochondrial membrane 34; anti-Tomm34 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: Mouse IgG1
• Clone Number: Tomm34-4.1
• Specificity: The mouse monoclonal antibody Tomm34-4.1 recognizes an epitope within TPR2 domain of human Tomm34 protein.
• Purity/Purification: Purified by protein-A affinity chromatography
• Form/Format: Purified. Phosphate buffered saline (PBS) solution with 15mM sodium azide
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-Tomm34 antibody: Western Blot (WB), Immunocytochemistry (ICC), Immunoprecipitation (IP)
• Immunogen: Recombinant human Tomm34
• Preparation and Storage: Store at 2-8 degree C. Do not freeze. Do not use after expiration date stamped on the label.

Related Product Information for anti-Tomm34 antibody

Tomm34 (Translocase of the outer mitochondrial membrane 34) is an additional component of the cellular chaperone system involved in protein folding. As the name suggests, Tomm34 was initially identified as being involved in mitochondrial protein processing. Subsequent studies have shown that Tomm34 interacts with both Hsp70 and Hsp90 and modifies their protein folding activities. In cancer, high levels of Tomm34 have been reported in bladder, colorectal and breast cancers compared to their normal tissue counterparts. In these cancers, Tomm34 promotes colorectal cancer cell growth and is a biomarker of poor outcome in early invasive breast cancer and bladder cancer. As a tumour-associated protein, Tomm34 peptide vaccination is under investigation as a therapeutic option for colorectal cancer, with significant Tomm34 cytotoxic T-lymphocyte (CTL) response observed.

References

*Müller P, Coates PJ, Nenutil R, Tr?ka F, Hrstka R, Chovanec J, Brychtová V, Vojt?šek B: Tomm34 is commonly expressed in epithelial ovarian cancer and associates with tumour type and high FIGO stage. J Ovarian Res. 2019 Mar 27;12(1):30., URL: https://pubmed.ncbi.nlm.nih.gov/30917858/

NCBI and Uniprot Product Information

• NCBI GI #: 21361356
• NCBI GeneID: 10953
• NCBI Accession #: NP_006800.2
• NCBI GenBank Nucleotide #: NM_006809.4
• UniProt Accession #: Q15785; Q53GH9; Q6IBN7; Q9NTZ3
• Molecular Weight: 34,559 Da
• NCBI Official Full Name: mitochondrial import receptor subunit TOM34
• NCBI Official Synonym Full Names: translocase of outer mitochondrial membrane 34
• NCBI Official Symbol: TOMM34
• NCBI Official Synonym Symbols: TOM34; URCC3; HTOM34P
• NCBI Protein Information: mitochondrial import receptor subunit TOM34; hTom34; outer mitochondrial membrane translocase (34kD); translocase of outer membrane 34 kDa subunit
• UniProt Protein Name: Mitochondrial import receptor subunit TOM34
• Protein Family: Mitochondrial import receptor
• UniProt Gene Name: TOMM34
• UniProt Synonym Gene Names: URCC3; hTom34
• UniProt Entry Name: TOM34_HUMAN

NCBI Description

The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats. [provided by RefSeq, Jul 2008]

Uniprot Description

TOMM34: Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state. Belongs to the Tom34 family.

Protein type: Chaperone; Mitochondrial

Chromosomal Location of Human Ortholog: -

Cellular Component: nucleoplasm; mitochondrial outer membrane; membrane; cytoplasm; integral to membrane; nucleus

Molecular Function: heat shock protein binding

Biological Process: protein targeting to mitochondrion