Rabbit anti-Human ZN673 Polyclonal Antibody | anti-ZN673 antibody

ZN673, CT (ZNF673, Protein ZNF673) (AP)

Cat. Num. AAA6365546

• Gene Names: KRBOX4; ZNF673
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: ZN673; Polyclonal Antibody; CT (ZNF673; Protein ZNF673) (AP); ZNF673; Protein ZNF673; anti-ZN673 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
• Sequence Length: 93

• Applicable Applications for anti-ZN673 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: ZN673 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-125 amino acids from the C-terminal region of human ZN673.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(ZN673 Antibody (C-term) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the ZN673 antibody detected the ZN673 protein (arrow).)

Related Product Information for anti-ZN673 antibody

ZNF673 belongs to the krueppel C2H2-type zinc-finger protein family. ZNF673 may be involved in transcriptional regulation. Defects in ZNF673 may be the cause of mental retardation X-linked type 92 (MRX92). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.

Product Categories/Family for anti-ZN673 antibody

Antibodies; Transcription Factors; Zinc (Ring) Finger

References

Lugtenberg, D., et al. Am. J. Hum. Genet. 78(2):265-278(2006). Ross, M.T., et al. Nature 434(7031):325-337(2005). Thiselton, D.L., et al. Genomics 79(4):560-572(2002).

NCBI and Uniprot Product Information

• NCBI GI #: 193804929
• NCBI GeneID: 55634
• NCBI Accession #: NP_001123372.1; NP_001123371.1
• NCBI GenBank Nucleotide #: NP_001123372.1
• UniProt Accession #: Q5JUW0
• NCBI Official Full Name: KRAB domain-containing protein 4 isoform 4
• NCBI Official Synonym Full Names: KRAB box domain containing 4
• NCBI Official Symbol: KRBOX4
• NCBI Official Synonym Symbols: ZNF673
• NCBI Protein Information: KRAB domain-containing protein 4
• UniProt Protein Name: KRAB domain-containing protein 4
• UniProt Gene Name: KRBOX4
• UniProt Synonym Gene Names: ZNF673
• UniProt Entry Name: KRBX4_HUMAN

NCBI Description

This encodes a zinc finger protein with an N-terminal KRAB (Kruppel-associated) domain found in transcriptional repressors. This gene is located in a region of the X chromosome thought to be involved in nonsyndromic X-linked cognitive disability. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Uniprot Description

ZNF673: This encodes a zinc finger protein with an N-terminal KRAB (Kruppel-associated) domain found in transcriptional repressors. This gene is located in a region of the X chromosome thought to be involved in nonsyndromic X-linked mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Protein type: C2H2-type zinc finger protein; Transcription regulation

Chromosomal Location of Human Ortholog: Xp11.3

Cellular Component: intracellular

Molecular Function: nucleic acid binding

Biological Process: regulation of transcription, DNA-dependent