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Flow Cytometry (FC/FACS) (Flow cytometry analysis (surface staining) of human peripheral blood leukocytes with anti-human CD157 (SY11B5) purified / GAM-APC.)

Mouse CD157 Monoclonal Antibody | anti-CD157 antibody

Anti-Hu CD157 Purified

Gene Names
BST1; CD157
Reactivity
Non-human primates, Human
Applications
Flow Cytometry, Functional Assay, Immunoprecipitation, Western Blot, Immunohistochemistry
Purity
Purified by Protein-A Affinity Chromatography
Synonyms
CD157; Monoclonal Antibody; Anti-Hu CD157 Purified; bone marrow stromal cell antigen 1; BST1; cADPr hydrolase 2; anti-CD157 antibody
Ordering
For Research Use Only!
Host
Mouse
Reactivity
Non-human primates, Human
Clonality
Monoclonal
Isotype
IgG1 kappa
Clone Number
SY11B5
Specificity
The mouse monoclonal antibody SY11B5 recognizes CD157, an approximately 45 kDa GPI-anchored extracellular protein expressed mainly on monocytes, macrophages, granulocytes and bone marrow stromal cells.
Purity/Purification
Purified by Protein-A Affinity Chromatography
Form/Format
Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Concentration
1 mg/ml (varies by lot)
Sequence Length
318
Applicable Applications for anti-CD157 antibody
Flow Cytometry (FC/FACS), Immunoprecipitation (IP), Western Blot (WB), Immunohistochemistry (IHC) Frozen
Application Notes
FC/FACS: QC tested
Immunogen
Human CD157
Preparation and Storage
Store at 2-8 degree C.

Flow Cytometry (FC/FACS)

(Flow cytometry analysis (surface staining) of human peripheral blood leukocytes with anti-human CD157 (SY11B5) purified / GAM-APC.)

Flow Cytometry (FC/FACS) (Flow cytometry analysis (surface staining) of human peripheral blood leukocytes with anti-human CD157 (SY11B5) purified / GAM-APC.)
Related Product Information for anti-CD157 antibody
CD157 (cADPr hydrolase 2) is a GPI-anchored ectoenzyme possessing ADP-ribosyl cyclase and cyclic ADP-ribose hydrolase activity. It uses NAD and cADP-ribose as substrates. CD157 is expressed on granulocytes, monocytes, macrophages, follicular dendritic cells, bone marrow stromal cells and human umbilical cord vein endothelial cells. In case of rheumatoid arthritis is expression is often higher and it is also differentially expressed in the myeloid leukemias. It may also have a signaling role.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
683
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
NCBI Official Synonym Full Names
bone marrow stromal cell antigen 1
NCBI Official Symbol
BST1
NCBI Official Synonym Symbols
CD157
NCBI Protein Information
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
UniProt Protein Name
ADP-ribosyl cyclase 2
UniProt Gene Name
BST1
UniProt Synonym Gene Names
BST-1
UniProt Entry Name
BST1_HUMAN

NCBI Description

Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population. [provided by RefSeq, Jul 2008]

Uniprot Description

BST1: Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth. Belongs to the ADP-ribosyl cyclase family.

Protein type: Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Hydrolase; EC 3.2.2.6; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 4p15

Cellular Component: extrinsic to membrane; plasma membrane

Molecular Function: transferase activity; phosphorus-oxygen lyase activity; NAD+ nucleosidase activity; NAD(P)+ nucleosidase activity

Biological Process: metabolic process; multicellular organismal development; positive regulation of B cell proliferation; humoral immune response

Research Articles on CD157

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Product Notes

The CD157 bst1 (Catalog #AAA1801560) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-Hu CD157 Purified reacts with Non-human primates, Human and may cross-react with other species as described in the data sheet. AAA Biotech's CD157 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), Immunoprecipitation (IP), Western Blot (WB), Immunohistochemistry (IHC) Frozen. FC/FACS: QC tested. Researchers should empirically determine the suitability of the CD157 bst1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD157, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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