Mouse anti-Rat CD28 Monoclonal Antibody | anti-CD28 antibody

Anti-Rt CD28 Purified

Cat. Num. AAA1800823

• Gene Names: Cd28; CD28RNA
• Reactivity: Rat
• Applications: Flow Cytometry, Functional Assay, Immunoprecipitation
• Purity: Purified by Protein-A Affinity Chromatography
• Synonyms: CD28; Monoclonal Antibody; Anti-Rt CD28 Purified; CD28 molecule; Tp44; anti-CD28 antibody

• Host: Mouse
• Reactivity: Rat
• Clonality: Monoclonal
• Isotype: IgG1 kappa
• Clone Number: JJ319
• Specificity: The mouse monoclonal antibody JJ319 reacts with an extracellular epitope of CD28, a disulfide-linked homodimeric type I glycoprotein (monomer of Mw 44 kDa) which is a critical costimulatory receptor of T cells.
• Purity/Purification: Purified by Protein-A Affinity Chromatography
• Form/Format: Phosphate buffered saline (PBS) solution with 15 mM sodium azide
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 218

• Applicable Applications for anti-CD28 antibody: Flow Cytometry (FC/FACS), Immunoprecipitation (IP)
• Application Notes: FC/FACS: QC tested
• Immunogen: Mouse A20J B lymphoma cells transfected with rat CD28
• Preparation and Storage: Store at 2-8 degree C.

Related Product Information for anti-CD28 antibody

CD28 is the critical T cell costimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. Besides its costimulation role CD28 functions in preventing T cells from anergic hyporesponsive state or from undergoing premature apoptotic cell death. CD28 is also expressed on human fetal NK cells and some NK cell lines, whereas on murine NK cells the CD28 expression is much broader.

NCBI and Uniprot Product Information

• NCBI GI #: 6978625
• NCBI GeneID: 25660
• NCBI Accession #: NP_037253.1
• NCBI GenBank Nucleotide #: NP_037253.1
• UniProt Accession #: P31042
• NCBI Official Full Name: T-cell-specific surface glycoprotein CD28
• NCBI Official Synonym Full Names: Cd28 molecule
• NCBI Official Symbol: Cd28
• NCBI Official Synonym Symbols: CD28RNA
• NCBI Protein Information: T-cell-specific surface glycoprotein CD28
• UniProt Protein Name: T-cell-specific surface glycoprotein CD28
• Protein Family: T-cell-specific surface glycoprotein
• UniProt Gene Name: Cd28
• UniProt Entry Name: CD28_RAT

NCBI Description

costimulatory molecule involved in induction of T cell proliferation and initiation of the Th2 response; may be important in maintanence of basal IgE production; binds to B7-1 or B7-2 on antigen presenting cells (APCs) [RGD, Feb 2006]

Uniprot Description

Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation.