Rabbit Band 4.1-like protein 1 Polyclonal Antibody | anti-EPB41L1 antibody

Anti-EPB41L1 Antibody

Cat. Num. AAA177411

• Gene Names: EPB41L1; 4.1N; MRD11
• Reactivity: Human, Mouse, Rat. No cross reactivity with other proteins.
• Applications: Western Blot
• Purity: Immunogen affinity purified.
• Synonyms: Band 4.1-like protein 1; Polyclonal Antibody; Anti-EPB41L1 Antibody; 4.1N antibody; Band 4.1 like protein 1 antibody; Band 4.1-like protein 1 antibody; DKFZp686H17242 antibody; E41L1_HUMAN antibody; EPB41L 1 antibody; Epb41l1 antibody; Erythrocyte membrane protein band 4.1 like 1 antibody; KIAA0338 antibody; MGC11072 antibody; MRD11 antibody; Neuron type nonerythroid protein 4.1 antibody; Neuronal protein 4.1 antibody; Nonerythroid protein 4.1 antibody; Nonerythroid protein 4.1; neuron type antibody; OTTHUMP00000030825 antibody; OTTHUMP00000030826 antibody; OTTHUMP00000030827 antibody; OTTHUMP00000030829 antibody; erythrocyte membrane protein band 4.1-like 1; anti-EPB41L1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat. No cross reactivity with other proteins.
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Immunogen affinity purified.
• Form/Format: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Sequence Length: 880

• Applicable Applications for anti-EPB41L1 antibody: Western Blot (WB)
• Application Notes: Western Blot: Concentration: 0.1-0.5mug/ml; Tested Species: Human, Mouse, Rat
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
• Immunogen: E.coli-derived human EPB41L1 recombinant protein (Position: Q691-S881). Human EPB41L1 shares 91% amino acid (aa) sequence identity with both mouse and rat EPB41L1.
• Preparation and Storage: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Western Blot (WB)

(Anti- EPB41L1 Picoband antibody, MBS177411, Western blottingAll lanes: Anti EPB41L1 (MBS177411) at 0.5ug/mlWB: Recombinant Human EPB41L1 Protein 0.5ngPredicted bind size: 50KDObserved bind size: 50KD )

Western Blot (WB)

(Anti- EPB41L1 Picoband antibody, MBS177411, Western blottingAll lanes: Anti EPB41L1 (MBS177411) at 0.5ug/mlLane 1: Rat Brain Tissue Lysate at 50ugLane 2: Mouse Brain Tissue Lysate at 50ugLane 3: A549 Whole Cell Lysate at 40ugPredicted bind size: 98KD Observed bind size: 98KD)

Related Product Information for anti-EPB41L1 antibody

Description: Rabbit IgG polyclonal antibody for Band 4.1-like protein 1(EPB41L1) detection. Tested with WB in Human;Mouse;Rat.
Background: Band 4.1-like protein 1 is a protein that in humans is encoded by the EPB41L1 gene. This gene is mapped to 20q11.23. It is found that a heterozygous missense mutation in the EPB41L1 gene causing nonsyndromic intellectual disability. This gene may function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. What's more, EPB41L1 is a multifunctional protein that mediates interactions between the erythrocyte cytoskeleton and the overlying plasma membrane.

NCBI and Uniprot Product Information

• NCBI GI #: 385251397
• NCBI GeneID: 2036
• NCBI Accession #: NP_001245258.1
• NCBI GenBank Nucleotide #: NM_001258329.1
• UniProt Accession #: Q9H4G0; O15046; Q4VXM6; Q4VXM7; Q4VXM8; Q4VXN4; Q6ZT61; Q8IUU7; Q96CV5; Q96L65
• Molecular Weight: 78,831 Da
• NCBI Official Full Name: band 4.1-like protein 1 isoform c
• NCBI Official Synonym Full Names: erythrocyte membrane protein band 4.1-like 1
• NCBI Official Symbol: EPB41L1
• NCBI Official Synonym Symbols: 4.1N; MRD11
• NCBI Protein Information: band 4.1-like protein 1; neuronal protein 4.1; neuron-type nonerythroid protein 4.1
• UniProt Protein Name: Band 4.1-like protein 1
• Protein Family: Band 4.1-like protein
• UniProt Gene Name: EPB41L1
• UniProt Synonym Gene Names: KIAA0338; 4.1N
• UniProt Entry Name: E41L1_HUMAN

NCBI Description

Erythrocyte membrane protein band 4.1 (EPB41) is a multifunctional protein that mediates interactions between the erythrocyte cytoskeleton and the overlying plasma membrane. The protein encoded by this gene is a neuronally-enriched protein that is structurally similar to EPB41. The encoded protein binds and stabilizes D2 and D3 dopamine receptors at the neuronal plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Uniprot Description

EPB41L1: May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. Defects in EPB41L1 are the cause of mental retardation autosomal dominant type 11 (MRD11). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 20q11.2-q12

Cellular Component: extrinsic to membrane; cytoskeleton; plasma membrane; cytosol

Molecular Function: actin binding; structural molecule activity

Biological Process: synaptic transmission; cortical actin cytoskeleton organization and biogenesis

Disease: Mental Retardation, Autosomal Dominant 11