Western Blot (WB)
(Anti-mouse Growth Hormone antibody, MBS176203, Western blottingLane 1: Recombinant Mouse GH Protein 10ngLane 2: Recombinant Mouse GH Protein 5ngLane 3: Recombinant Mouse GH Protein 2 )
Rabbit anti-Mouse Growth Hormone Polyclonal Antibody | anti-GH1 antibody
Anti-mouse Growth Hormone antibody
Western Blot (WB)
(Anti-mouse Growth Hormone antibody, MBS176203, Western blottingLane 1: Recombinant Mouse GH Protein 10ngLane 2: Recombinant Mouse GH Protein 5ngLane 3: Recombinant Mouse GH Protein 2 )
Western Blot (WB)
(Anti-mouse Growth Hormone antibody, MBS176203, Western blottingLane 1: Recombinant Mouse GH Protein 10ngLane 2: Recombinant Mouse GH Protein 5ngLane 3: Recombinant Mouse GH Protein 2 )
Background: Growth Hormone(GH) is mapped to 17q22-q24. Growth hormone(GH) is synthesized by acidophilic or somatotropic cells of the anterior pituitary gland. Human growth hormone has a molecular mass of 22,005 and contains 191 amino acid residues with 2 disulfide bridges. It binds two receptor molecules and thereby induces signal transduction through receptor dimerization. At high concentrations, GH acts as an antagonist because of a large difference in affinities at the respective binding sites.
NCBI and Uniprot Product Information
Uniprot Description
GH: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Defects in GH1 are a cause of growth hormone deficiency isolated type 1A (IGHD1A); also known as pituitary dwarfism I. IGHD1A is an autosomal recessive deficiency of GH which causes short stature. IGHD1A patients have an absence of GH with severe dwarfism and often develop anti-GH antibodies when given exogenous GH. Defects in GH1 are a cause of growth hormone deficiency isolated type 1B (IGHD1B); also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. Dwarfism is less severe than in IGHD1A and patients usually respond well to exogenous GH. Defects in GH1 are the cause of Kowarski syndrome (KWKS); also known as pituitary dwarfism VI. Defects in GH1 are a cause of growth hormone deficiency isolated type 2 (IGHD2). IGHD2 is an autosomal dominant deficiency of GH which causes short stature. Clinical severity is variable. Patients have a positive response and immunologic tolerance to growth hormone therapy. Belongs to the somatotropin/prolactin family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted; Hormone
Cellular Component: extracellular space; mitochondrion; plasma membrane; extracellular region; trans-Golgi network; cytosol; nucleus; secretory granule
Molecular Function: growth hormone receptor binding; hormone activity; metal ion binding
Biological Process: response to food; response to light stimulus; positive regulation of neurogenesis; cellular response to insulin stimulus; neuroblast proliferation; positive regulation of multicellular organism growth; regulation of steroid hormone receptor signaling pathway; glucose transport; signal transduction; alveolus development; positive regulation of growth
Research Articles on GH1
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Product Notes
The GH1 gh1 (Catalog #AAA176203) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-mouse Growth Hormone antibody reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Growth Hormone can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the GH1 gh1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Growth Hormone, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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