Typical Testing Data/Standard Curve (for reference only)
(Mouse IL-1 alpha PicoKine ELISA Kit standard curve )
Mouse IL-1 alpha ELISA Kit | IL1A elisa kit
Mouse IL-1 alpha PicoKine ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
(Mouse IL-1 alpha PicoKine ELISA Kit standard curve )
Typical Testing Data/Standard Curve (for reference only)
(Mouse IL-1 alpha PicoKine ELISA Kit standard curve )
Background: Interleukin-1 alpha (IL-1 alpha) and interleukin-1 beta (IL-1 beta) are two biochemically distinct, but distantly related, polypeptidic cytokines that play a key role in inflammation, immunologic reactions, and tissue repair.1 IL-1 alpha hasbeen implicated in the pathogenesis of infectious, autoimmune and inflammatory diseases.2 Recently, it has beenshown that IL-1 alpha is identical to hematopoietin 1, which is described as a hematopoietic growth factor acting on early progenitor cells in synergy with other hematopoietic growth factors.1 The human interleukin 1 alpha gene isassigned to chromosome 2.3 Genetic polymorphisms at interleukin (IL-1alpha and IL-1beta) have been recentlysuggested to be associated with severity of adult periodontitis.4 The murine IL-1 alpha and IL-1 beta genes encodestructurally and evolutionarily related cytokines that exert a regulatory role in numerous physiological processes including hemopoiesis.5 The standard product used in this kit is recombinant mouse IL-1alpha with the molecular massof 18kDa.
NCBI and Uniprot Product Information
Uniprot Description
IL1A: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. Belongs to the IL-1 family.
Protein type: Motility/polarity/chemotaxis; Cytokine
Cellular Component: extracellular space; cell surface; plasma membrane; extracellular region; cytosol
Molecular Function: interleukin-1 receptor binding; copper ion binding; cytokine activity
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of mitosis; positive regulation of interleukin-2 biosynthetic process; cytokine and chemokine mediated signaling pathway; germ cell programmed cell death; positive regulation of JNK cascade; positive regulation of interleukin-6 production; fever; positive regulation of stress-activated MAPK cascade; negative regulation of cell proliferation; positive regulation of angiogenesis; connective tissue replacement during inflammatory response; response to copper ion; positive regulation of cell division; keratinization; positive regulation of prostaglandin secretion; immune response; positive regulation of transcription from RNA polymerase II promoter; regulation of sensory perception of pain; inflammatory response; positive regulation of cytokine secretion
Research Articles on IL1A
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Product Notes
The Mouse IL1A il1a (Catalog #AAA175805) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA175805 ELISA Kit recognizes Mouse IL1A. It is sometimes possible for the material contained within the vial of "IL-1 alpha, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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