Western Blot (WB)
(Anti-GABA Transporter 1/GAT 1 antibody, MBS175748, Western blottingLane 1: Rat Brain Tissue LysateLane 2: Mouse Brain Tissue Lysate )
Rabbit GABA Transporter 1/GAT 1 Polyclonal Antibody | anti-SLC6A1 antibody
Anti-GABA Transporter 1/GAT 1 antibody
Western Blot (WB)
(Anti-GABA Transporter 1/GAT 1 antibody, MBS175748, Western blottingLane 1: Rat Brain Tissue LysateLane 2: Mouse Brain Tissue Lysate )
Western Blot (WB)
(Anti-GABA Transporter 1/GAT 1 antibody, MBS175748, Western blottingLane 1: Rat Brain Tissue LysateLane 2: Mouse Brain Tissue Lysate )
Immunohistochemistry (IHC)
(Anti-GABA Transporter 1/GAT 1 antibody, MBS175748, IHC(P)IHC(P): Rat Brain Tissue )
Immunohistochemistry (IHC)
(Anti-GABA Transporter 1/GAT 1 antibody, MBS175748, IHC(P)IHC(P): Rat Brain Tissue )
Background: SLC6A1(Solute Carrier family 6(Neurotransmitter transporter, Gaba), Member 1), also called GABATR or GABATHG, encodes a gamma-aminobutyric acid(GABA) transporter, which removes GABA from the synaptic cleft. The SLC6A1 gene contains 15 exons and is approximately 25 kb by Lam et al. And it is mapped on 3p25.3. Zomot et al.(2007) showed that introduction of a negatively charged amino acid at or near 1 of the 2 putative sodium binding sites of the GABA transporter GAT1 from rat brain(also calledSLC6A1) renders both net flux and exchange of GABA largely chloride independent. By in vitro functional expression studies, the SLC6A1 insertion promoter(2 copies of the sequence) had significantly greater promoter activity than the noninsertion(1 copy of the sequence) promoter, which in turn had greater activity than a promoterless control. Studies of postmortem hippocampus from 69 African American individuals showed that the SLC6A1promoter genotype predicted SLC6A1 RNA expression and that overall SLC6A1 expression decreased with age.
NCBI and Uniprot Product Information
NCBI Description
The SLC6A1 gene encodes a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft (Hirunsatit et al., 2009 [PubMed 19077666]).[supplied by OMIM, Jul 2009]
Uniprot Description
SLC6A1: Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A1 subfamily.
Protein type: Transporter, SLC family; Membrane protein, multi-pass; Transporter; Membrane protein, integral
Chromosomal Location of Human Ortholog: 3p25.3
Cellular Component: cell surface; membrane; integral to plasma membrane; axon; integral to membrane; plasma membrane
Molecular Function: gamma-aminobutyric acid:sodium symporter activity; neurotransmitter:sodium symporter activity
Biological Process: response to purine; response to toxin; neurotransmitter secretion; learning; response to cocaine; response to estradiol stimulus; response to sucrose stimulus; synaptic transmission; transport; response to lead ion; gamma-aminobutyric acid import; negative regulation of synaptic transmission, GABAergic; response to calcium ion; transmembrane transport; protein homooligomerization; positive regulation of gamma-aminobutyric acid secretion
Disease: Myoclonic-atonic Epilepsy
Research Articles on SLC6A1
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Product Notes
The SLC6A1 slc6a1 (Catalog #AAA175748) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-GABA Transporter 1/GAT 1 antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's GABA Transporter 1/GAT 1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Researchers should empirically determine the suitability of the SLC6A1 slc6a1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GABA Transporter 1/GAT 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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