Western Blot (WB)
(Anti-Caveolin-2 antibody, MBS175735, Western blottingLane 1: Rat Heart Tissue LysateLane 2: Rat lung Tissue LysateLane 3: HELA Cell LysateLane 4: A431 Cell Lysate )
Rabbit Caveolin-2 Polyclonal Antibody | anti-CAV2 antibody
Anti-Caveolin-2 antibody
Western Blot (WB)
(Anti-Caveolin-2 antibody, MBS175735, Western blottingLane 1: Rat Heart Tissue LysateLane 2: Rat lung Tissue LysateLane 3: HELA Cell LysateLane 4: A431 Cell Lysate )
Western Blot (WB)
(Anti-Caveolin-2 antibody, MBS175735, Western blottingLane 1: Rat Heart Tissue LysateLane 2: Rat lung Tissue LysateLane 3: HELA Cell LysateLane 4: A431 Cell Lysate )
Western Blot (WB)
(Anti-Caveolin-2 antibody, MBS175735, Western blottingAll lanes: Anti Caveolin-2 (MBS175735) at 0.5ug/mlLane 1: HELA Whole Cell Lysate at 40ugLane 2: SMMC Whole Cell Lysate at 40ugLane 3: COLO320 Whole Cell Lysate at 40ugPredicted bind size: 17KDObserved bind size: 17KD )
Western Blot (WB)
(Anti-Caveolin-2 antibody, MBS175735, Western blottingAll lanes: Anti Caveolin-2 (MBS175735) at 0.5ug/mlLane 1: HELA Whole Cell Lysate at 40ugLane 2: SMMC Whole Cell Lysate at 40ugLane 3: COLO320 Whole Cell Lysate at 40ugPredicted bind size: 17KDObserved bind size: 17KD )
Immunohistochemistry (IHC)
(Anti-Caveolin-2 antibody, MBS175735, IHC(P)IHC(P): Human Lung Cancer Tissue )
Immunohistochemistry (IHC)
(Anti-Caveolin-2 antibody, MBS175735, IHC(P)IHC(P): Human Lung Cancer Tissue )
Immunohistochemistry (IHC)
(Anti-Caveolin-2 antibody, MBS175735, IHC(P)IHC(P): Rat Cardiac Muscle Tissue )
Immunohistochemistry (IHC)
(Anti-Caveolin-2 antibody, MBS175735, IHC(P)IHC(P): Rat Cardiac Muscle Tissue )
Background: Caveolin-2 is a protein related to caveolin-1 which is derived caveolin-enriched membranes. CAV2 and CAV1 are similar in most respects and they differ in their functional interactions with heterotrimeric G proteins. Caveolin-1 and caveolin-2 are expressed in neuronal cells. Caveolin-2 was upregulated in response to neuronal cell injury. The CAV2 gene is mapped to 7q31.1-q31.2. The CAV1 gene contains 3 exons, while the human CAV2 gene contains 2 exons. The boundary of the last exon of CAV1 and CAV2 are analogous, suggesting that they arose through gene duplication. The genes encoding murine caveolin-1 and -2 are colocalized within the A2 region of mouse chromosome 6.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462). [provided by RefSeq, May 2011]
Uniprot Description
Caveolin-2: a scaffolding protein. A component of caveolae, small invaginations of the plasma membrane found in most cell types. Involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-2 may function as an accessory protein in conjunction with caveolin-1. Two splice-variant isoforms have been observed.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7q31.1
Cellular Component: Golgi apparatus; protein complex; focal adhesion; integral to plasma membrane; caveola; lipid raft; acrosomal membrane; Golgi membrane; transport vesicle; extrinsic to internal side of plasma membrane; membrane; perinuclear region of cytoplasm; plasma membrane; cytoplasmic vesicle; intracellular; nucleus
Molecular Function: protein binding; protein homodimerization activity; D1 dopamine receptor binding
Biological Process: vesicle fusion; endoplasmic reticulum organization and biogenesis; mitochondrion organization and biogenesis; positive regulation of dopamine receptor signaling pathway; vesicle docking; positive regulation of MAPKKK cascade; vesicle organization and biogenesis; negative regulation of endothelial cell proliferation; insulin receptor signaling pathway; regulation of mitosis; skeletal muscle fiber development; positive regulation of endothelial cell proliferation; negative regulation of transforming growth factor beta receptor signaling pathway; protein oligomerization; positive regulation of GTPase activity
Research Articles on CAV2
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Product Notes
The CAV2 cav2 (Catalog #AAA175735) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Caveolin-2 antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Caveolin-2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Researchers should empirically determine the suitability of the CAV2 cav2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Caveolin-2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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