Western Blot (WB)
(Anti-Hex antibody, MBS175605, Western blottingLane 1: Rat Liver Tissue LysateLane 2: Rat Thymus Tissue LysateLane 3: Rat Lung Tissue LysateLane 4: Rat Pancreas Tissue LysateLane 5: HT1080 Cell LysateLane 6: MM453 Cell LysateLane 7: SMMC Cell LysateLane 8: 6T-CEM Cell LysateLane 9: COLO320 Cell Lysate)
Rabbit Hex Polyclonal Antibody | anti-HHEX antibody
Anti-Hex antibody
Western Blot (WB)
(Anti-Hex antibody, MBS175605, Western blottingLane 1: Rat Liver Tissue LysateLane 2: Rat Thymus Tissue LysateLane 3: Rat Lung Tissue LysateLane 4: Rat Pancreas Tissue LysateLane 5: HT1080 Cell LysateLane 6: MM453 Cell LysateLane 7: SMMC Cell LysateLane 8: 6T-CEM Cell LysateLane 9: COLO320 Cell Lysate)
Western Blot (WB)
(Anti-Hex antibody, MBS175605, Western blottingLane 1: Rat Liver Tissue LysateLane 2: Rat Thymus Tissue LysateLane 3: Rat Lung Tissue LysateLane 4: Rat Pancreas Tissue LysateLane 5: HT1080 Cell LysateLane 6: MM453 Cell LysateLane 7: SMMC Cell LysateLane 8: 6T-CEM Cell LysateLane 9: COLO320 Cell Lysate)
Background: Hematopoietically-expressed homeobox protein HHEX is a protein that in humans is encoded by the HHEX gene. Homeobox genes are members of a family of transcription factors that regulate tissue development in many different organisms. Hromas et al.(1993) set out to identify homeobox genes that might play a role in hematopoiesis. And using somatic cell hybrid analysis, they mapped the HHEX gene to chromosome 10, where the HOX11 gene is located. Homeobox genes are involved in neoplastic transformation of both epithelial and hemopoietic tissues. The divergent homeobox gene HEX is expressed in the anterior visceral endoderm during early mouse development and in some adult tissues of endodermal origin, including liver and thyroid. D'Elia et al.'s findings suggested that regulation of HEX entry in the nucleus of thyrocytes may represent a critical step during human thyroid tumorigenesis.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation. [provided by RefSeq, Jul 2008]
Uniprot Description
HHEX: Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 10q23.33
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding; protein homodimerization activity; TATA-binding protein binding; sequence-specific DNA binding; eukaryotic initiation factor 4E binding; chromatin binding; DNA bending activity; transcription factor binding
Biological Process: response to peptide hormone stimulus; negative regulation of transcription from RNA polymerase II promoter; anterior/posterior pattern formation; poly(A)+ mRNA export from nucleus; pancreas development; thyroid gland development; response to wounding; vasculogenesis; cell differentiation; positive regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway; negative regulation of vascular endothelial growth factor receptor signaling pathway; transcription, DNA-dependent; in utero embryonic development; multicellular organism growth; negative regulation of cyclin-dependent protein kinase activity; forebrain morphogenesis; interkinetic nuclear migration; regulation of cell proliferation; cell proliferation; negative regulation of angiogenesis; mRNA export from nucleus; B cell differentiation; myeloid leukocyte differentiation; embryonic heart tube development; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; endoderm development
Research Articles on HHEX
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Product Notes
The HHEX hhex (Catalog #AAA175605) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Hex antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Hex can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the HHEX hhex for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Hex, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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