Western Blot (WB)
(Anti-CD168 antibody, MBS175430, Western blottingLane 1: MM231 Cell LysateLane 2: MM453 Cell LysateLane 3: HELA Cell LysateLane 4: A549 Cell Lysate )
Rabbit anti-Human CD168 Polyclonal Antibody | anti-HMMR antibody
Anti-CD168 antibody
Gene Names
HMMR; CD168; IHABP; RHAMM
Reactivity
Human
Applications
Western Blot, Immunohistochemistry
Purity
Immunogen affinity purified.
Synonyms
CD168; Polyclonal Antibody; Anti-CD168 antibody; Hyaluronan mediated motility receptor; hyaluronan-mediated motility receptor(RHAMM); CD168 antibody; CD168 antigen antibody; HMMR antibody; HMMR_HUMAN antibody; Hyaluronan mediated motility receptor antibody; Hyaluronan-mediated motility receptor(RHAMM) antibody; IHABP antibody; Intracellular hyaluronic acid-binding protein antibody; MGC119494 antibody; MGC119495 antibody; OTTHUMP00000196920 antibody; Receptor for hyaluronan-mediated motility antibody; RHAMM antibody; anti-HMMR antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Immunogen affinity purified.
Form/Format
Lyophilized
Sequence Length
724
Applicable Applications for anti-HMMR antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human CD168 (706-724aa KEGNTNCYRAPMECQESWK).
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Western Blot (WB)
(Anti-CD168 antibody, MBS175430, Western blottingLane 1: MM231 Cell LysateLane 2: MM453 Cell LysateLane 3: HELA Cell LysateLane 4: A549 Cell Lysate )
Western Blot (WB)
(Anti-CD168 antibody, MBS175430, Western blottingLane 1: MM231 Cell LysateLane 2: MM453 Cell LysateLane 3: HELA Cell LysateLane 4: A549 Cell Lysate )
Immunohistochemistry (IHC)
(Anti-CD168 antibody, MBS175430, IHC(P)IHC(P): Human Placenta Tissue )
Immunohistochemistry (IHC)
(Anti-CD168 antibody, MBS175430, IHC(P)IHC(P): Human Placenta Tissue )
Related Product Information for anti-HMMR antibody
Description: Rabbit IgG polyclonal antibody for Hyaluronan mediated motility receptor(HMMR) detection. Tested with WB, IHC-P in Human.
Background: HMMR, Hyaluronan-mediated motility receptor, is a protein which in humans is encoded by the HMMR gene. RHAMM was originally discovered as a soluble protein that altered migratory cell behavior and bound to hyaluronan, HMMR is less well studied than the main hyaluronan(HA) receptor, CD44. In contrast to CD44 and other cell-surface receptors which contain the classical membrane spanning domain and signal sequence for secretion from the endoplasmic reticulum/Golgi complex, HMMR does not contain a membrane spanning domain nor does the mRNA transcript contain a signal sequence. HMMR normally is localized inside the cell and is only release by certain, poorly defined stimuli. The transport of HMMR to the extracellular space still is unclear but may involve transport channels or proteins, flippase activity, or exocytosis. Intracellularly, HMMR associates with microtubules and, working with BRCA1 and BARD1, plays a role in the regulation of mitosis. Extracellularly, HMMR associates with CD44, and upon binding to HA, activates intracellular signaling pathways. Variants of HMMR caused by alternative splicing have been observed, but not thoroughly studied.
Background: HMMR, Hyaluronan-mediated motility receptor, is a protein which in humans is encoded by the HMMR gene. RHAMM was originally discovered as a soluble protein that altered migratory cell behavior and bound to hyaluronan, HMMR is less well studied than the main hyaluronan(HA) receptor, CD44. In contrast to CD44 and other cell-surface receptors which contain the classical membrane spanning domain and signal sequence for secretion from the endoplasmic reticulum/Golgi complex, HMMR does not contain a membrane spanning domain nor does the mRNA transcript contain a signal sequence. HMMR normally is localized inside the cell and is only release by certain, poorly defined stimuli. The transport of HMMR to the extracellular space still is unclear but may involve transport channels or proteins, flippase activity, or exocytosis. Intracellularly, HMMR associates with microtubules and, working with BRCA1 and BARD1, plays a role in the regulation of mitosis. Extracellularly, HMMR associates with CD44, and upon binding to HA, activates intracellular signaling pathways. Variants of HMMR caused by alternative splicing have been observed, but not thoroughly studied.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
74,495 Da
NCBI Official Full Name
Hyaluronan mediated motility receptor
NCBI Official Synonym Full Names
hyaluronan-mediated motility receptor (RHAMM)
NCBI Official Symbol
HMMR
NCBI Official Synonym Symbols
CD168; IHABP; RHAMM
NCBI Protein Information
hyaluronan mediated motility receptor; receptor for hyaluronan-mediated motility; intracellular hyaluronic acid-binding protein
UniProt Protein Name
Hyaluronan mediated motility receptor
Protein Family
UniProt Gene Name
HMMR
UniProt Synonym Gene Names
IHABP; RHAMM
UniProt Entry Name
HMMR_HUMAN
NCBI Description
The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008]
Uniprot Description
HMMR: Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular- regulated kinase (ERK) activity. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, misc.
Chromosomal Location of Human Ortholog: 5q34
Cellular Component: cell surface; membrane; cytoplasm; plasma membrane
Molecular Function: hyaluronic acid binding
Biological Process: glycosaminoglycan metabolic process; carbohydrate metabolic process; pathogenesis; hyaluronan metabolic process; hyaluronan catabolic process
Disease: Breast Cancer
Research Articles on HMMR
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Product Notes
The HMMR hmmr (Catalog #AAA175430) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-CD168 antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CD168 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Researchers should empirically determine the suitability of the HMMR hmmr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD168, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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