Rabbit anti-Mouse KK gamma Polyclonal Antibody | anti-IKBKG antibody

Anti-KK gamma antibody

Cat. Num. AAA175365

• Gene Names: Ikbkg; NEMO; IKK[g]; AI848108; AI851264; AW124339; 1110037D23Rik
• Reactivity: Mouse
• Applications: Western Blot
• Purity: Immunogen affinity purified.
• Synonyms: KK gamma; Polyclonal Antibody; Anti-KK gamma antibody; NF-kappa-B essential modulator(NEMO); inhibitor of kappa light polypeptide gene enhancer in B-cells; kinase gamma; IkB kinase associated protein 1 antibody; IkB kinase subunit gamma antibody; Inhibitor of nuclear factor kappa B kinase subunit gamma antibody; AMCBX1 antibody; FIP 3 antibody; FIP-3 antibody; FIP3 antibody; Fip3p antibody; I kappa B kinase gamma antibody; I-kappa-B kinase subunit gamma antibody; IkB kinase gamma subunit antibody; IkB kinase-associated protein 1 antibody; IKBKG antibody; IKK-gamma antibody; IKKAP 1 antibody; IKKAP1 antibody; IKKG antibody; Incontinentia pigmenti antibody; Inhibitor of kappa light polypeptide gene enhancer in B cells kinase gamma antibody; Inhibitor of kappa light polypeptide gene enhancer in B cells; kinase gamma antibody; Inhibitor of nuclear factor kappa B kinase gamma subunit antibody; Inhibitor of nuclear factor kappa-B kinase subunit gamma antibody; IP 1 antibody; IP 2 antibody; IP antibody; IP1 antibody; IP2 antibody; IPD2 antibody; NEMO antibody; NEMO_HUMAN antibody; NF kappa B essential modifier antibody; NF kappa B essential modulator antibody; NF kappaB essential modifier antibody; NF kappaB essential modulator antibody; NF-kappa-B essential modifier antibody; NF-kappa-B essential modulator antibody; NFkappaB essential modulator antibody; ZC2HC9 antibody; anti-IKBKG antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Immunogen affinity purified.
• Form/Format: Lyophilized
• Sequence Length: 412

• Applicable Applications for anti-IKBKG antibody: Western Blot (WB)
• Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of mouse KK gamma (1-15aa MNKHPWKNQLSEMVQ), different from the relative rat sequence by three amino acids.
• Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
• Preparation and Storage: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Western Blot (WB)

(Anti-IKK gamma antibody, MBS175365, Western blottingLane 1: Mouse Liver Tissue LysateLane 2: Mouse Brain Tissue LysateLane 3: Mouse Ovary Tissue Lysate )

Related Product Information for anti-IKBKG antibody

Description: Rabbit IgG polyclonal antibody for NF-kappa-B essential modulator(IKBKG) detection. Tested with WB in Mouse.
Background: IKBKG(Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase of, gamma) is also known as NEMO. The IKK complex is composed of IKK-alpha, IKK-beta, and 2 other polypeptides of 50 and 52 kD which are differentially processed forms of a third subunit, IKK-gamma. The 419-amino acid IKK-gamma protein is composed of several potential coiled-coil motifs and a leucine zipper motif. NEMO interacted with IKK2(IKK-beta), but not with IKK1(IKK-alpha). IKK-gamma forms dimers and trimers and interacts preferentially with IKK-beta.

NCBI and Uniprot Product Information

• NCBI GI #: 341941165
• NCBI GeneID: 16151
• UniProt Accession #: O88522; Q924H4
• Molecular Weight: 47,972 Da
• NCBI Official Full Name: NF-kappa-B essential modulator
• NCBI Official Synonym Full Names: inhibitor of kappaB kinase gamma
• NCBI Official Symbol: Ikbkg
• NCBI Official Synonym Symbols: NEMO; IKK[g]; AI848108; AI851264; AW124339; 1110037D23Rik
• NCBI Protein Information: NF-kappa-B essential modulator; IKKG; IKKAP1; mFIP-3; IKK-gamma; ikB kinase subunit gamma; NF-kappa-B essential modifier; I-kappa-B kinase subunit gamma; ikB kinase-associated protein 1; inhibitor of nuclear factor kappa-B kinase subunit gamma; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
• UniProt Protein Name: NF-kappa-B essential modulator
• UniProt Gene Name: Ikbkg
• UniProt Synonym Gene Names: Nemo; NEMO; IKKAP1; mFIP-3; I-kappa-B kinase subunit gamma; IKK-gamma; IKKG; IkB kinase subunit gamma
• UniProt Entry Name: NEMO_MOUSE

Uniprot Description

IKKG: a regulatory subunit of the IKK-signalosome complex. Interacts preferentially with IKK-beta but also able to interact with IKK-alpha, IKAP, TAX, RIP and MAP3K14/NIK. Defects are the cause of familial incontinentia pigmenti type II (IP2).

Protein type: Adaptor/scaffold; Protein kinase, regulatory subunit

Cellular Component: spindle pole; cytoplasm; IkappaB kinase complex; intracellular; cytosol; nucleus; ubiquitin ligase complex

Molecular Function: protein domain specific binding; peroxisome proliferator activated receptor binding; protein binding; protein homodimerization activity; protein heterodimerization activity; metal ion binding; ubiquitin protein ligase binding

Biological Process: establishment of vesicle localization; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of transcription, DNA-dependent; B cell homeostasis; transcription, DNA-dependent; activation of NF-kappaB-inducing kinase; positive regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus; activation of NF-kappaB transcription factor