Low Density Lipoprotein (LDL) Antigen | LDL antigen

Low Density Lipoprotein (AcLDL) - Acetylated; Low Density Lipoprotein, Acetylated

• Gene Names: LDLR; FH; FHC; FHCL1; LDLCQ2
• Applications: Clinical Chemistry, Lipids, Cardiac
• Purity: >= 95% (SDS-PAGE)
• Synonyms: Low Density Lipoprotein (LDL); Low Density Lipoprotein (AcLDL) - Acetylated; Low Density Lipoprotein; Acetylated; Ac-LDL; AcLDL; LDL antigen

• Host: Human Plasma
• Purity/Purification: >= 95% (SDS-PAGE)
• Form/Format: Liquid. 0.2 micron filteredLiquid. Solution in 20 mM tris chloride, 150 mM sodium chloride and 0.01% EDTA, pH 7.4.
• Concentration: > 1 mg/mL (Coomassie) (varies by lot)
• Sequence Length: 76

• Applicable Applications for LDL antigen: Clinical Chemistry, Lipids, Cardiac
• Application Notes: Clinical calibration control; Source of antigens for developing antibodies; Cholesterol Research in regards to pharmaceutical drug development and familial hypercholesterolaemia (Varghese, 2014); Developing new methods of LDL measurement (Nauck, Warnick, & Rifai, 2002)
• Protein: >1 mg/mL (Coomassie)
• Handling: Product is packaged aseptically and stored under nitrogen to prevent oxidation.
• Electrophoresis: One major band consistent with LDL, HDL not detected (Helena QuickGel Cholesterol)
• Infectious Disease Testing: Negative or non-reactive at the donor level for anti-HIV 1 and 2, anti-HCV, HBsAg, HIV-1 (NAT), HBV (NAT), HCV (NAT), and syphilis by FDA approved methods.
• Emerging Research: LDL size has been shown to be linked to cardiovascular health. The larger the LDL particles, the greater correlation to a cardiovascular event. (Foroutan, MS, RDN, 2015); Lowering LDL to the levels of a new-born baby has been shown to dramatically decrease the risk of heart disease. (News Medical Life Sciences, 2016); Direct homogeneous assays rather than determining LDL-C values based on the Friedewald calculation may improve lipoprotein analyses and allow for a more accurate LDL value, especially in regards to patients suffering from hyperlipidemia (Nauck, Warnick, & Rifai, 2002).
• Preparation and Storage: Store at 2-8 degree C.

Related Product Information for LDL antigen

Low-density lipoprotein (LDL), often deemed the "bad cholesterol", is a lipoprotein that carries cholesterol throughout the body via blood circulation. Due to its role in dispositioning cholesterol TO tissues and organs of the body, having high levels of LDL can lead to plaque formation in the arteries, possibly increasing the risk of heart disease and stroke. (American Heart Association, 2014)
It is recommended by the National Heart, Lung, and Blood Institute to maintain a LDL cholesterol level lower than 100 mg/dL, optimally. (National Heart, Lung, and Blood Institute, 2016)

Product Categories/Family for LDL antigen

Antigens; Enzymes; Antigens; Standards; Controls; Proteins; Low Density Lipoprotein (acldl) - Acetylated

NCBI and Uniprot Product Information

• NCBI GI #: 306411097
• NCBI GeneID: 3949
• Molecular Weight: 2.75 million (ref. Tetz second Edition)
• NCBI Official Full Name: low density lipoprotein, partial
• NCBI Official Synonym Full Names: low density lipoprotein receptor
• NCBI Official Symbol: LDLR
• NCBI Official Synonym Symbols: FH; FHC; FHCL1; LDLCQ2
• NCBI Protein Information: low-density lipoprotein receptor

NCBI Description

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]