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Prostatic Acid Phosphatase Active Protein | ACPP active protein

Prostatic Acid Phosphatase (PAP/ACP), Human

Gene Names
ACP2; LAP
Purity
Partially Purified
Synonyms
Prostatic Acid Phosphatase; Prostatic Acid Phosphatase (PAP/ACP); Human; ACP; PAP; Acid Phos; 5'-nucleotidase; 5'-NT; Ecto-5'-nucleotidase; Thiamine monophosphatase; TMPase; PAPf39; Prostatic Acid Phosphatase (ACP; PAP); Human Semen - Lyophilized; ACPP active protein
Ordering
For Research Use Only!
Purity/Purification
Partially Purified
Form/Format
Lyophilized
Appearance: Off-white powder
Sequence Length
423
Source
Human Semen
EC Number
3.1.3.2
Unit Definition
One unit will catalyze the hydrolysis of one micromole of thymolphthalein monophosphate to thymolphthalein and phosphate per minute at pH 5.6 and 37 degree C.
Specific Activity
Typically >= 30 U/mg protein
Solubility
Clear, colorless solution (10 mg/mL saline)
Recertification
3 years
Protein
>= 0.2 protein/mg (Coomassie/Biuret)
CAS Number
9001-77-8
Activity
5 - 15 U/mg solid (Dimension Clinical Chemistry System)
Preparation and Storage
At -20 degree C
Related Product Information for ACPP active protein
MyBioSource produces human Prostatic Acid Phosphatase (PAP/ACP) for research,life science and manufacturing uses.

Custom preparations, technical support, bulk quantities and aliquoting available.

What is Human Acid Phosphatase? Human Prostate Acid Phosphatase also known as human prostatic acid phosphatase (PAP,ACP) is alternative marker to Prostate Specific Antigen (PSA) for prostate malignancy. Rape investigations will often include testing for the presence of Human prostatic (prostate) acid phosphatase in vaginal fluid.

The highest levels of acid phosphatase are found in metastasized prostate cancer. Diseases of the bone, such as Paget's disease or hyperparathyroidism, diseases of blood cells, such as sickle-cell disease or multiple myeloma or lysosomal storage diseases, such as Gaucher's disease, will show moderately increased levels.

Human Prostate Acid Phosphatase also known as human prostatic acid phosphatase (PAP, ACP) is alternative marker to prostate specific antigen (PSA) for prostate malignancy. Rape investigations will often include testing for the presence of Human prostatic (prostate) acid phosphatase in vaginal fluid.

Human prostatic Acid phosphatase (PAP) is a phosphatase, a type of enzyme, used to free attached phosphate groups from other molecules during digestion. Acid Phosphatase is stored in lysosomes and functions when these fuse with endosomes, which are acidified while they function; therefore,Human Acid Phosphatase has an acid pH optimum below 7.0.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
53
UniProt Accession #
Molecular Weight
~100,000
NCBI Official Full Name
acid phosphatase
NCBI Official Synonym Full Names
acid phosphatase 2, lysosomal
NCBI Official Symbol
ACP2
NCBI Official Synonym Symbols
LAP
NCBI Protein Information
lysosomal acid phosphatase
UniProt Protein Name
Lysosomal acid phosphatase
UniProt Gene Name
ACP2
UniProt Synonym Gene Names
LAP
UniProt Entry Name
PPAL_HUMAN

NCBI Description

This gene encodes the beta subunit of lysosomal acid phosphatase (LAP). LAP is chemically and genetically distinct from red cell acid phosphatase. The encoded protein belongs to a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. LAP-deficiencies in mice cause multiple defects including bone structure alterations, lysosomal storage defects in the kidneys and central nervous system, and an increased tendency towards seizures. An enzymatically-inactive allele of LAP in mice exhibited a more severe phenotype than the null allele, and defects included cerebellum abnormalities, growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

Uniprot Description

ACP2: Defects in ACP2 are a cause of acid phosphatase deficiency (ACPHD). The clinical features are intermittent vomiting, hypotonia, lethargy, opisthotonos, terminal bleeding, and death in early infancy. Lysosomal acid phosphatase is deficient in cultured fibroblasts and multiple tissues. Belongs to the histidine acid phosphatase family.

Protein type: EC 3.1.3.2; Motility/polarity/chemotaxis; Phosphatase (non-protein); Cofactor and Vitamin Metabolism - riboflavin; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11p11.2|11p12-p11

Cellular Component: lysosomal lumen; membrane; lysosomal membrane; lysosome; integral to membrane

Molecular Function: acid phosphatase activity

Biological Process: dephosphorylation; lysosome organization and biogenesis; skeletal development

Disease: Acid Phosphatase Deficiency

Research Articles on ACPP

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Product Notes

The ACPP acp2 (Catalog #AAA173168) is an Active Protein and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Prostatic Acid Phosphatase, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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