Fatty Acid Binding Protein | h-FABP protein

Fatty Acid Binding Protein (FABP), Human Heart

• Purity: >= 98% (SDS-PAGE, single bad at approximately 15 kDa).
• Synonyms: Fatty Acid Binding Protein; Fatty Acid Binding Protein (FABP); Human Heart; h-FABP; FABP; Fatty acid binding protein 3; Human FABP; h-FABP protein

• Purity/Purification: >= 98% (SDS-PAGE, single bad at approximately 15 kDa).
• Form/Format: Frozen solution in 0.01 M sodium phosphate, 0.15 M sodium chloride, pH 7.2 with 0.05 % sodium azide.
• Sequence Length: 801

• Source: Human Heart
• Protein: 2.6 mg protein/mL (E^0.1%280nm=0.94).
• Handling: Handle as a potentially hazardous substance
• Recovery: Centrifuge briefly to ensure complete recovery.
• Preparation and Storage: Store at -20°C . Avoid freeze/thaws.

Related Product Information for h-FABP protein

MyBioSource sells Human Heart Fatty Acid Binding Protein for research and development and manufacture.

Custom preparations, technical support, bulk quantities and aliquoting available.

Human Fatty Acid Binding Proteins are tissue specific intracellular molecules. They are a class of cytoplasmic proteins that bind long chain fatty acid and play an important role in the intracellular utilization of fatty acids. In Acute Mycardial Infarction (AMI), FABP is rapidly released from damaged cardiomyocytes into the circulation due to its small size.

Product Categories/Family for h-FABP protein

Proteins; Antigens; Standards/controls; Native Proteins; Fatty Acid Binding Protein (fabp)

NCBI and Uniprot Product Information

• NCBI GI #: 157427691
• NCBI GeneID: 646486
• NCBI Accession #: NP_001098751.1
• NCBI GenBank Nucleotide #: NM_001105281.1
• UniProt Accession #: P05556; P78466; P78467; Q13089; Q13090; Q13091; Q13212; A8K6N2; D3DRX9; D3DRY3; D3DRY4; D3DRY5; A6NFH5
• Molecular Weight: 14, 700
• NCBI Official Full Name: fatty acid-binding protein 12
• NCBI Official Synonym Full Names: fatty acid binding protein 12
• NCBI Official Symbol: FABP12
• NCBI Protein Information: fatty acid-binding protein 12; fatty acid binding protein ORF; intracellular fatty acid-binding protein FABP12; Probable fatty acid-binding protein ENSP00000353650
• UniProt Protein Name: Integrin beta-1
• Protein Family: Fatty acid binding protein
• UniProt Gene Name: ITGB1
• UniProt Synonym Gene Names: FNRB; MDF2; MSK12; GPIIA
• UniProt Entry Name: ITB1_HUMAN

Uniprot Description

ITGB1: an integral membrane protein that heterodimerizes with an alpha-3 chain, forming a receptor for many extracellular-matrix proteins including fibronectin, laminin, collagen, epiligrin and thrombospondin. . Beta 1 integrins recognize the amino-acid motif RGD in a wide array of ligands. Five alternatively spliced variants with alternate carboxy termini have been described. Two alternatively spliced isoforms have been described. Isoform beta-1a is widely expressed; other isoforms are generally expressed with a more restricted distribution. Isoform beta-1b is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoforms beta-1c and beta-1c-2 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform beta-c-2, rather than isoform beta-1c, is selectively expressed in primary t-cells. Isoform beta-1c is expressed in nonproliferating and differentiated prostate gland epithelial cells. Isoform beta-1d is expressed specifically in striated muscle (skeletal and cardiac muscle).

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion; Cell surface; Receptor, misc.

Chromosomal Location of Human Ortholog: 10p11.2

Cellular Component: cell surface; focal adhesion; acrosome; dendritic spine; lipid raft; ruffle; recycling endosome; membrane; hemidesmosome; lamellipodium; cytoplasm; plasma membrane; melanosome; basement membrane; integrin complex; neuromuscular junction; receptor complex; sarcolemma; filopodium; external side of plasma membrane; cleavage furrow

Molecular Function: protein domain specific binding; protease binding; metal ion binding; laminin binding; actin binding; alpha-actinin binding; protein kinase binding; peptide binding; integrin binding; viral receptor activity; protein binding; protein heterodimerization activity; fibronectin binding; cell adhesion molecule binding; glycoprotein binding

Biological Process: axon guidance; extracellular matrix organization and biogenesis; entry of virus into host cell; maternal process involved in pregnancy; positive regulation of apoptosis; axon extension; regulation of cell cycle; cell-matrix adhesion; mesodermal cell differentiation; cell fate specification; positive regulation of endocytosis; cardiac muscle cell differentiation; negative regulation of cell proliferation; leukocyte adhesion; positive regulation of MAPKKK cascade; transforming growth factor beta receptor signaling pathway; positive regulation of cell proliferation; germ cell migration; tissue homeostasis; visual learning; negative regulation of cell projection organization and biogenesis; response to drug; integrin-mediated signaling pathway; regulation of immune response; cell migration; in utero embryonic development; dendrite morphogenesis; sarcomere organization; protein transport within lipid bilayer; cell-substrate adhesion; cellular calcium ion homeostasis; formation of radial glial scaffolds; heterotypic cell-cell adhesion; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of neuron differentiation; cell migration during sprouting angiogenesis; negative regulation of Rho protein signal transduction; B cell differentiation; cell-cell adhesion mediated by integrin; calcium-independent cell-matrix adhesion; stress fiber formation; cellular defense response; response to activity; homophilic cell adhesion; leukocyte tethering or rolling; blood coagulation; leukocyte migration; regulation of G-protein coupled receptor protein signaling pathway; positive regulation of cell migration; G1/S transition of mitotic cell cycle