Creatine Kinase MM Active Protein | CKM active protein

Creatine Kinase MM (CK-MM), Human Skeletal Muscle

• Gene Names: CKM; CKMM; M-CK
• Purity: >= 96% (SDS-PAGE)
• Synonyms: Creatine Kinase MM; Creatine Kinase MM (CK-MM); Human Skeletal Muscle; CK-MM; CKMM; Human Skeletal Muscle - 50% Glycerol; CKM active protein

• Purity/Purification: >= 96% (SDS-PAGE)
• Form/Format: 50% Glycerol; Appearance: Light to dark amber liquid
• Sequence Length: 381

• Source: Human Skeletal Muscle
• EC Number: 2.7.3.2
• Unit Definition: One unit will catalyze the transphosphorylation of one micromole of phosphate from creatine phosphate to ADP per minute at 37 degree C.
• Specific Activity: >= 500 U/mg protein
• Recertification: 2 years
• Protein: >= 5.0 mg/mL (Coomassie)
• Isozyme Content: CK-MM: >= 99%, CK-BB: < 1%, CK-MB: < 1% (Helena QuickGel CK)
• Contaminants: GOT/AST: <=0.01%, LDH: <=0.01% (Dimension Clinical Chemistry System)
• CAS Number: 9001-15-4
• Activity: >= 1,000 U/mL (Dimension Clinical Chemistry System)
• Preparation and Storage: At -20 degree C

Related Product Information for CKM active protein

MyBioSource is the leading manufacturer of human muscle Creatine Kinase MM (CKMM,CK-MM) for medical research and manufacturing.

Custom preparations, technical support, bulk quantities and aliquoting available.

Human CKMM isoenzyme, also known as human CPK-3 isoenzyme, is normally responsible for almost all human CPK enzyme activity in healthy individuals. When human CK-MM isoenzyme is elevated, this usually indicates injury or stress to skeletal muscle.

Product Categories/Family for CKM active protein

Proteins; Antigens; Enzymes; Standards/controls; Native Proteins; Immunogen; Creatine Kinase Mm (ck-mm)

NCBI and Uniprot Product Information

• NCBI GI #: 21536288
• NCBI GeneID: 1158
• NCBI Accession #: NP_001815.2
• NCBI GenBank Nucleotide #: NM_001824.4
• UniProt Accession #: P06732; Q96QL9
• Molecular Weight: 43,101 Da
• NCBI Official Full Name: creatine kinase M-type
• NCBI Official Synonym Full Names: creatine kinase, muscle
• NCBI Official Symbol: CKM
• NCBI Official Synonym Symbols: CKMM; M-CK
• NCBI Protein Information: creatine kinase M-type; creatine kinase M chain
• UniProt Protein Name: Creatine kinase M-type
• Protein Family: Creatine kinase
• UniProt Gene Name: CKM
• UniProt Synonym Gene Names: CKMM
• UniProt Entry Name: KCRM_HUMAN

NCBI Description

The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. [provided by RefSeq, Jul 2008]

Uniprot Description

CKM: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. Belongs to the ATP:guanido phosphotransferase family.

Protein type: EC 2.7.3.2; Kinase, other; Amino Acid Metabolism - arginine and proline

Chromosomal Location of Human Ortholog: 19q13.32

Cellular Component: cytosol

Molecular Function: creatine kinase activity; ATP binding

Biological Process: phosphocreatine biosynthetic process; phosphorylation; creatine metabolic process