MPST recombinant protein

Recombinant Human MPST protein

Cat. Num. AAA1562481

• Gene Names: MPST; MST; TST2; TUM1
• Purity: >90% as determined by SDS-PAGE
• Synonyms: MPST; Recombinant Human MPST protein; 3-mercaptopyruvate sulfurtransferase; Short name:MST; MPST recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 0.2% NLS, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Species: Homo sapiens (Human)
• Protein Construction: A DNA sequence encoding the human MPST (Met1-Ala156) was fused with His tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Related Product Information for MPST recombinant protein

Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H2S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions.

Product Categories/Family for MPST recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 61835204
• NCBI GeneID: 4357
• NCBI Accession #: NP_001013454.1
• NCBI GenBank Nucleotide #: NM_001013436.2
• UniProt Accession #: P25325; O75750; Q6FHN9; A8MZ34; B3KP52; J3KPV7
• NCBI Official Full Name: 3-mercaptopyruvate sulfurtransferase isoform 2
• NCBI Official Synonym Full Names: mercaptopyruvate sulfurtransferase
• NCBI Official Symbol: MPST
• NCBI Official Synonym Symbols: MST; TST2; TUM1
• NCBI Protein Information: 3-mercaptopyruvate sulfurtransferase; human liver rhodanese; tRNA thiouridin modification protein 1
• UniProt Protein Name: 3-mercaptopyruvate sulfurtransferase
• Protein Family: 3-mercaptopyruvate sulfurtransferase
• UniProt Gene Name: MPST
• UniProt Synonym Gene Names: TST2; MST
• UniProt Entry Name: THTM_HUMAN

NCBI Description

This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU). Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

MPST: Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. May have a role in cyanide degradation or in thiosulfate biosynthesis.

Protein type: Transferase; Amino Acid Metabolism - cysteine and methionine; EC 2.8.1.2; Mitochondrial

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: neuron projection; mitochondrial inner membrane; synapse; cell junction

Molecular Function: 3-mercaptopyruvate sulfurtransferase activity; thiosulfate sulfurtransferase activity

Biological Process: cyanate catabolic process; response to toxin