mLY75 recombinant protein

Recombinant Human mLY75 protein

Cat. Num. AAA1561258

• Purity: >90% as determined by SDS-PAGE
• Synonyms: mLY75; Recombinant Human mLY75 protein; Lymphocyte antigen 75; Ly-75; C-type lectin domain family 13 member B; DEC-205; gp200-MR6; CD205; mLY75 recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 0.2% NLS, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Species: Homo sapiens (Human)
• Protein Construction: A DNA sequence encoding the human mLY75 (Cys216-Cys501) was fused with His tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Related Product Information for mLY75 recombinant protein

LY75 knockdown in SKOV3 cells also resulted in predominant upregulation of functional pathways implicated in cell proliferation and metabolism, while pathways associated with cell signaling and adhesion, complement activation and immune response were mostly suppressed. Moreover, LY75 suppression had an opposite effect on EOC cell lines with epithelial phenotype (A278s and OV28), by directing epithelial-to-mesenchymal transition (EMT) associated with reduced capacity for in vivo EOC cell colonization, as similar/identical signaling pathways were reversely regulated, when compared to mesenchymal LY75 knockdown EOC cells.

Product Categories/Family for mLY75 recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 311771583
• NCBI GeneID: 100526664
• NCBI Accession #: NP_001185688.1
• NCBI GenBank Nucleotide #: NM_001198759.1
• UniProt Accession #: O60449; O75913; Q53R46; Q53TF5; Q7Z575; Q7Z577
• Molecular Weight: 198,311 Da
• NCBI Official Full Name: LY75-CD302 fusion protein isoform 1
• NCBI Official Synonym Full Names: LY75-CD302 readthrough
• NCBI Official Symbol: LY75-CD302
• NCBI Protein Information: LY75-CD302 fusion protein; DEC-205/DCL-1 fusion
• UniProt Protein Name: Lymphocyte antigen 75
• UniProt Gene Name: LY75
• UniProt Synonym Gene Names: CD205; CLEC13B; Ly-75
• UniProt Entry Name: LY75_HUMAN

NCBI Description

This locus represents naturally occurring read-through transcription between the neighboring lymphocyte antigen 75 (LY75) and CD302 molecule (CD302) genes. Alternative splicing results in multiple transcript variants encoding fusion products that share sequence identity with each individual gene product. [provided by RefSeq, Nov 2010]

Uniprot Description

LY75: Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen- processing compartment. Causes reduced proliferation of B-lymphocytes. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q24

Cellular Component: integral to plasma membrane

Molecular Function: receptor activity; carbohydrate binding

Biological Process: endocytosis; immune response; inflammatory response