FOLR1 recombinant protein

Recombinant Human FOLR1 protein, C-His Tag

Cat. Num. AAA1560668

• Gene Names: FOLR1; FBP; FOLR
• Purity: >90% as determined by SDS-PAGE
• Synonyms: FOLR1; Recombinant Human FOLR1 protein; C-His Tag; FOLR; FOLR1 recombinant protein

• Host: Mammalian cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Tag: C-His Tag
• Species: Homo sapiens (Human)
• Endotoxin Level: <1.0EU per ug of the protein as determined by the LAL method.
• Protein Construction: A DNA sequence encoding the human FOLR1 (Met1- Met233) was fused with the C-terminal His Tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

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Product Categories/Family for FOLR1 recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 4758400
• NCBI GeneID: 2348
• NCBI Accession #: NP_000793.1
• NCBI GenBank Nucleotide #: NM_000802.3
• UniProt Accession #: P15328; Q53EW2; Q6FGT8; Q6LC90; Q9UCT2
• Molecular Weight: 29,819 Da
• NCBI Official Full Name: folate receptor alpha
• NCBI Official Synonym Full Names: folate receptor 1 (adult)
• NCBI Official Symbol: FOLR1
• NCBI Official Synonym Symbols: FBP; FOLR
• NCBI Protein Information: folate receptor alpha; FR-alpha; KB cells FBP; folate binding protein; folate receptor, adult; adult folate-binding protein; ovarian tumor-associated antigen MOv18
• UniProt Protein Name: Folate receptor alpha
• Protein Family: Folate receptor
• UniProt Gene Name: FOLR1
• UniProt Synonym Gene Names: FOLR; FR-alpha; FBP
• UniProt Entry Name: FOLR1_HUMAN

NCBI Description

The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]

Uniprot Description

FOLR1: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brain- specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy, and leukodystrophy. Recognition and diagnosis of this disorder is critical because folinic acid therapy can reverse the clinical symptoms and improve brain abnormalities and function. Belongs to the folate receptor family.

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 11q13.3-q14.1

Cellular Component: anchored to external side of plasma membrane; cell surface; membrane; clathrin-coated vesicle; brush border membrane; integral to plasma membrane; apical plasma membrane; plasma membrane; endosome

Molecular Function: folic acid transporter activity; receptor activity; folic acid binding

Biological Process: receptor-mediated endocytosis; folic acid metabolic process; folic acid transport

Disease: Neurodegeneration Due To Cerebral Folate Transport Deficiency