CD123 recombinant protein

Recombinant Human CD123 protein, C-His Tag

Cat. Num. AAA1560574

• Gene Names: IL3RA; IL3R; CD123; IL3RX; IL3RY; IL3RAY; hIL-3Ra
• Purity: >90% as determined by SDS-PAGE
• Synonyms: CD123; Recombinant Human CD123 protein; C-His Tag; IL3R; IL3RA; IL-3Ra; IL-3R-alpha; IL3RAY; IL3RX; IL3RY; CD123 antigen; hIL3Ra; hIL-3Ra; MGC34174; IL-3 R alpha; CD123 recombinant protein

• Host: Mammalian cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Tag: C-His Tag
• Species: Homo sapiens (Human)
• Endotoxin Level: <1.0EU per ug of the protein as determined by the LAL method.
• Protein Construction: A DNA sequence encoding the human IL3RA (Met1-Arg305) was fused with the C-terminal His Tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

SDS-Page

Related Product Information for CD123 recombinant protein

Interleukin 3 receptor alpha (low affinity) (IL3RA), also known as CD123 (Cluster of Differentiation 123) is a 70-kD glycoprotein member of the hematopoietin receptor superfamily. This protein associates with a beta subunit common to the receptors for IL-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF) to form a high-affinity receptor for IL-3. The interleukin-3 receptor alpha chain (CD123) has been identified as a potential immunotherapeutic target because it is overexpressed in AML compared with normal hematopoietic stem cells.

Product Categories/Family for CD123 recombinant protein

Protein

References

Rascu, Otelea, Mambet, Handra, Neagu, Rascu, Giurcaneanu, Diaconu (2020) Modified plasma cytokine profile in occupational dermatitis Endocrine, metabolic & immune disorders drug targets ()

NCBI and Uniprot Product Information

• NCBI GI #: 417184
• NCBI GeneID: 3563
• UniProt Accession #: P26951; Q5HYQ7; Q5HYQ8; Q9UEH7; A8K3F3; B9VI81
• Molecular Weight: 34,466 Da
• NCBI Official Full Name: Interleukin-3 receptor subunit alpha
• NCBI Official Synonym Full Names: interleukin 3 receptor, alpha (low affinity)
• NCBI Official Symbol: IL3RA
• NCBI Official Synonym Symbols: IL3R; CD123; IL3RX; IL3RY; IL3RAY; hIL-3Ra
• NCBI Protein Information: interleukin-3 receptor subunit alpha; IL-3RA; IL-3R-alpha; CD123 antigen; IL-3R subunit alpha; IL-3 receptor subunit alpha; IL-3 receptor alpha SP2 isoform
• UniProt Protein Name: Interleukin-3 receptor subunit alpha
• UniProt Gene Name: IL3RA
• UniProt Synonym Gene Names: IL3R; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha; IL-3RA
• UniProt Entry Name: IL3RA_HUMAN

NCBI Description

The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012]

Uniprot Description

IL3RA: This is a receptor for interleukin-3. Belongs to the type I cytokine receptor family. Type 5 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: Xp22.3 or Yp11.3

Cellular Component: plasma membrane; integral to membrane

Molecular Function: interleukin-3 receptor activity