LAMTOR3 blocking peptide

LAMTOR3 Peptide

Cat. Num. AAA154087

• Gene Names: LAMTOR3; MP1; MAPBP; MAPKSP1; PRO0633; MAP2K1IP1; Ragulator3
• Applications: Blocking (BL)
• Synonyms: LAMTOR3; LAMTOR3 Peptide; MP1; MAPBP; MAPKSP1; PRO0633; MAP2K1IP1; Ragulator3; PRO2783; Ragulator complex protein LAMTOR3; MEK-binding partner 1; Mp1; late endosomal/lysosomal adaptor; MAPK and MTOR activator 3; LAMTOR3 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 124

• Applicable Applications for LAMTOR3 blocking peptide: Blocking (BL)
• Application Notes: The peptide is used for blocking the activity of LAMTOR3 antibody. It usually blocks the antibody activity completely by incubating the peptide with equal volume of antibody for 30 min at 37 degree C.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 15 amino acid peptide near the center of human LAMTOR3.
• Preparation and Storage: Store LAMTOR3 peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 11496277
• NCBI GeneID: 8649
• NCBI Accession #: NP_068805
• NCBI GenBank Nucleotide #: NM_021970.3
• UniProt Accession #: Q9UHA4; Q9H364; B2R4A1; J3KMX4
• Molecular Weight: 12,941 Da
• NCBI Official Full Name: ragulator complex protein LAMTOR3 isoform 1
• NCBI Official Synonym Full Names: late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
• NCBI Official Symbol: LAMTOR3
• NCBI Official Synonym Symbols: MP1; MAPBP; MAPKSP1; PRO0633; MAP2K1IP1; Ragulator3
• NCBI Protein Information: ragulator complex protein LAMTOR3; MEK binding partner 1; MAPK scaffold protein 1; mitogen-activated protein kinase scaffold protein 1; late endosomal/lysosomal adaptor and MAPK and MTOR activator 3; mitogen-activated protein kinase kinase 1 interacting protein 1
• UniProt Protein Name: Ragulator complex protein LAMTOR3
• Protein Family: Ragulator complex protein
• UniProt Gene Name: LAMTOR3
• UniProt Synonym Gene Names: MAP2K1IP1; MAPKSP1; Mp1
• UniProt Entry Name: LTOR3_HUMAN

NCBI Description

This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. [provided by RefSeq, Aug 2011]

Uniprot Description

LAMTOR3: Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, recruits the Rag GTPases and the mTORC1 complex to lysosomes, a key step in activation of the TOR signaling cascade by amino acids. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. Interacts with MAP2K1/MEK1 and MAPK2. Interacts with MORG1. Part of the Ragulator complex composed of LAMTOR1, LAMTOR2 and LAMTOR3. Interacts with LAMTOR1; the interaction is direct. Belongs to the LAMTOR3 family.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 4q23

Cellular Component: focal adhesion

Molecular Function: protein binding; guanyl-nucleotide exchange factor activity; protein complex scaffold

Biological Process: positive regulation of TOR signaling pathway; positive regulation of GTPase activity