IQSEC2 blocking peptide

IQSEC2 Peptide

Cat. Num. AAA154053

• Gene Names: IQSEC2; MRX1; BRAG1
• Applications: Blocking (BL)
• Synonyms: IQSEC2; IQSEC2 Peptide; IQ motif and Sec7 domain 2; Brefeldin-resistant Arf-GEF 1 protein; BRAG1; MRX1; IQSEC2 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 1488

• Applicable Applications for IQSEC2 blocking peptide: Blocking (BL)
• Application Notes: IQSEC2 peptide is used for blocking the activity of IQSEC2 antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 18 amino acid peptide near the carboxy terminus of human IQSEC2.
• Preparation and Storage: Store IQSEC2 peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 162138911
• NCBI GeneID: 23096
• NCBI Accession #: NP_001104595
• NCBI GenBank Nucleotide #: NM_001111125.2
• UniProt Accession #: Q5JU85; O60275; Q5JUX1; B3KT97; C7SDG1
• Molecular Weight: 105,100 Da
• NCBI Official Full Name: IQ motif and SEC7 domain-containing protein 2 isoform 1
• NCBI Official Synonym Full Names: IQ motif and Sec7 domain 2
• NCBI Official Symbol: IQSEC2
• NCBI Official Synonym Symbols: MRX1; BRAG1
• NCBI Protein Information: IQ motif and SEC7 domain-containing protein 2; brefeldin A resistant Arf-guanine nucleotide exchange factor 1; brefeldin A resistant Arf-guanine nucleotide exchange factor 1b; brefeldin A resistant Arf-guanine nucleotide exchange factor 1c
• UniProt Protein Name: IQ motif and SEC7 domain-containing protein 2
• Protein Family: IQ motif and SEC7 domain-containing protein
• UniProt Gene Name: IQSEC2
• UniProt Synonym Gene Names: KIAA0522
• UniProt Entry Name: IQEC2_HUMAN

NCBI Description

This gene encodes a guanine nucleotide exchange factor for the ARF family of small GTP-binding proteins. The encoded protein is a component of the postsynaptic density at excitatory synapses, and may play a critical role in cytoskeletal and synaptic organization through the activation of selected ARF substrates including ARF1 and ARF6. Mutations in this gene have been implicated in nonsyndromic X-linked mental retardation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

Uniprot Description

IQSEC2: Defects in IQSEC2 are the cause of mental retardation X- linked type 1 (MRX1). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific X-linked mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation. Belongs to the BRAG family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs, ARF; GEFs

Chromosomal Location of Human Ortholog: Xp11.22

Cellular Component: trans-Golgi network; nucleus; cell junction

Molecular Function: ARF guanyl-nucleotide exchange factor activity

Biological Process: vesicle-mediated transport; regulation of ARF protein signal transduction; actin cytoskeleton organization and biogenesis; positive regulation of GTPase activity

Disease: Mental Retardation, X-linked 1