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Western Blot (WB) (Western blot analysis of RLN3 in HeLa cell lysate with RLN3 antibody at (A) 1 and (B) 2 μg/ml.)

Rabbit anti-Human RLN3 Polyclonal Antibody | anti-RLN3 antibody

RLN3 Antibody

Gene Names
RLN3; H3; RXN3; ZINS4; insl7
Reactivity
Human
Applications
ELISA, Western Blot
Purity
RLN3 antibody is affinity chromatography purified via peptide column.
Synonyms
RLN3; Polyclonal Antibody; RLN3 Antibody; Relaxin-3; RXN3; H3; ZINS4; INSL7; relaxin 3; anti-RLN3 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
RLN3 antibody is human specific. RLN3 antibody is predicted to not cross-react with other members of the Relaxin protein family.
Purity/Purification
RLN3 antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
142
Applicable Applications for anti-RLN3 antibody
ELISA (EIA), Western Blot (WB)
Application Notes
RLN3 antibody can be used for detection of RLN3 by Western blot at 1 - 2 mug/ml.
Conjugate
Unconjugated
Immunogen
RLN3 antibody was raised against a 19 amino acid peptide near the center of human RLN3.
Buffer
RLN3 antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
RLN3 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.

Western Blot (WB)

(Western blot analysis of RLN3 in HeLa cell lysate with RLN3 antibody at (A) 1 and (B) 2 μg/ml.)

Western Blot (WB) (Western blot analysis of RLN3 in HeLa cell lysate with RLN3 antibody at (A) 1 and (B) 2 μg/ml.)

Immunohistochemistry (IHC)

(Immunohistochemistry of RLN3 in human brain tissue with RLN3 antibody at 5 μg/mL.)

Immunohistochemistry (IHC) (Immunohistochemistry of RLN3 in human brain tissue with RLN3 antibody at 5 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of RLN3 in human brain tissue with RLN3 antibody at 20 μg/mL.)

Immunofluorescence (IF) (Immunofluorescence of RLN3 in human brain tissue with RLN3 antibody at 20 μg/mL.)
Related Product Information for anti-RLN3 antibody
Relaxin-3 (RLN3) is a member of Relaxin family, a group of endocrine and autocrine/paracrine hormones that belong to the insulin gene superfamily (1,2). RLN3 can bind to and activate three relaxin-family peptide receptors: RXFP1, RXFP3, and RXFP4 (3). In contrast to the widespread expression of the related proteins RLN1 and RLN2, RLN3 is predominantly expressed in brain and to a lesser extent in the thymus, kidney and spleen (1). RLN3 has been suggested to play a role in feeding, metabolism, stress, arousal, learning, and memory (4).

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
Predicted: 16 kDa

Observed: 20 kDa
NCBI Official Full Name
relaxin-3 preproprotein
NCBI Official Synonym Full Names
relaxin 3
NCBI Official Symbol
RLN3
NCBI Official Synonym Symbols
H3; RXN3; ZINS4; insl7
NCBI Protein Information
relaxin-3; prorelaxin H3; insulin-like 7; insulin-like peptide 7; insulin-like peptide INSL7
UniProt Protein Name
Relaxin-3
Protein Family
UniProt Gene Name
RLN3
UniProt Synonym Gene Names
INSL7; RXN3; ZINS4; Insulin-like peptide 7
UniProt Entry Name
REL3_HUMAN

NCBI Description

Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In the human there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3. RLN1 and RLN2 share high sequence homology. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. The protein encoded by this gene is a member of the relaxin family. The active form of the encoded protein consists of an A chain and a B chain but their cleavage sites are not definitely described yet. It may play a role in neuropeptide signaling processes. [provided by RefSeq, Jul 2008]

Uniprot Description

RLN3: May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142). Belongs to the insulin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: extracellular region

Molecular Function: protein binding; G-protein-coupled receptor binding; hormone activity

Research Articles on RLN3

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Product Notes

The RLN3 rln3 (Catalog #AAA153541) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RLN3 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's RLN3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). RLN3 antibody can be used for detection of RLN3 by Western blot at 1 - 2 mug/ml. Researchers should empirically determine the suitability of the RLN3 rln3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RLN3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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