Western Blot (WB)
(Western blot analysis of WAC in human testis tissue lysate with WAC antibody at 1 μg/mL.)
Rabbit WAC Polyclonal Antibody | anti-WAC antibody
WAC Antibody
Western Blot (WB)
(Western blot analysis of WAC in human testis tissue lysate with WAC antibody at 1 μg/mL.)
Western Blot (WB)
(Western blot analysis of WAC in human testis tissue lysate with WAC antibody at 1 μg/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of WAC in mouse testis tissue with WAC antibody at 2.5 μg/ml.)
Immunohistochemistry (IHC)
(Immunohistochemistry of WAC in mouse testis tissue with WAC antibody at 2.5 μg/ml.)
Immunofluorescence (IF)
(Immunofluorescence of WAC in mouse testis tissue with WAC antibody at 5 μg/ml.)
Immunofluorescence (IF)
(Immunofluorescence of WAC in mouse testis tissue with WAC antibody at 5 μg/ml.)
NCBI and Uniprot Product Information
Observed: 75 kDa
NCBI Description
The protein encoded by this gene contains a WW domain, which is a protein module found in a wide range of signaling proteins. This domain mediates protein-protein interactions and binds proteins containing short linear peptide motifs that are proline-rich or contain at least one proline. This gene product shares 94% sequence identity with the WAC protein in mouse, however, its exact function is not known. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Uniprot Description
WAC: Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. May negatively regulate the ubiquitin proteasome pathway. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 10p12.1|10p12.1-p11.2
Cellular Component: nucleoplasm; spliceosome; nuclear speck; nucleus
Molecular Function: protein binding; chromatin binding
Biological Process: histone monoubiquitination; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; response to DNA damage stimulus; positive regulation of macroautophagy
Research Articles on WAC
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Product Notes
The WAC wac (Catalog #AAA153531) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The WAC Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's WAC can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). WAC Antibody can be used for detection of WAC by Western blot at 1 mug/mL. Researchers should empirically determine the suitability of the WAC wac for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "WAC, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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