TYW1 blocking peptide

TYW1 Peptide

Cat. Num. AAA152078

• Gene Names: TYW1; TYW1A; RSAFD1; YPL207W
• Applications: Blocking (BL)
• Synonyms: TYW1; TYW1 Peptide; TYW1A; RSAFD1; YPL207W; S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase; Radical S-adenosyl methionine and flavodoxin domain-containing protein 1; tRNA-yW synthesizing protein 1 homolog (S. cerevisiae); TYW1 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 732

• Applicable Applications for TYW1 blocking peptide: Blocking (BL)
• Application Notes: TYW1 peptide is used for blocking the activity of TYW1 antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 19 amino acids near the carboxy terminus of human TYW1.
• Preparation and Storage: Store TYW1 peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 50726981
• NCBI GeneID: 55253
• NCBI Accession #: NP_060734
• NCBI GenBank Nucleotide #: NM_018264.3
• UniProt Accession #: Q9NV66; Q6PJG8; Q75MG8; Q75MN3; Q86V12; Q8IVS7; Q9H9C4
• Molecular Weight: 43,700 Da
• NCBI Official Full Name: S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
• NCBI Official Synonym Full Names: tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
• NCBI Official Symbol: TYW1
• NCBI Official Synonym Symbols: TYW1A; RSAFD1; YPL207W
• NCBI Protein Information: S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase; tRNA-yW synthesizing protein 1 homolog A; tRNA wybutosine-synthesizing protein 1 homolog; radical S-adenosyl methionine and flavodoxin domains 1; radical S-adenosyl methionine and flavodoxin domain-containing protein 1
• UniProt Protein Name: S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
• UniProt Gene Name: TYW1
• UniProt Synonym Gene Names: RSAFD1
• UniProt Entry Name: TYW1_HUMAN

NCBI Description

Wybutosine (yW) is a hypermodified guanosine found in phenylalanine tRNA adjacent to the anticodon that stabilizes codon-anticodon interactions in the ribosome. In yeast, the homolog of this gene is essential for the synthesis of wybutosine. [provided by RefSeq, Dec 2012]

Uniprot Description

TYW1: Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Belongs to the TYW1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA processing; Oxidoreductase; EC 4.1.3.44

Chromosomal Location of Human Ortholog: 7q11.21

Cellular Component: nucleoplasm; cytoplasm

Molecular Function: FMN binding; iron ion binding; 4 iron, 4 sulfur cluster binding; lyase activity; oxidoreductase activity

Biological Process: tRNA processing