Western Blot (WB)
(Western blot analysis of SPATA18 in rat lung tissue lysate with SPATA18 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide)
Chicken SPATA18 Polyclonal Antibody | anti-SPATA18 antibody
SPATA18 Antibody
Western Blot (WB)
(Western blot analysis of SPATA18 in rat lung tissue lysate with SPATA18 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide)
Western Blot (WB)
(Western blot analysis of SPATA18 in rat lung tissue lysate with SPATA18 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide)
NCBI and Uniprot Product Information
Uniprot Description
SPATA18: Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Belongs to the MIEAP family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Mitochondrial
Chromosomal Location of Human Ortholog: 4q12
Cellular Component: mitochondrial outer membrane; intracellular membrane-bound organelle; cytoplasm
Molecular Function: protein binding
Biological Process: response to DNA damage stimulus
Research Articles on SPATA18
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Product Notes
The SPATA18 spata18 (Catalog #AAA151481) is an Antibody produced from Chicken and is intended for research purposes only. The product is available for immediate purchase. The SPATA18 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SPATA18 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). SPATA18 antibody can be used for detection of SPATA18 by Western blot at 1 mug/mL. Researchers should empirically determine the suitability of the SPATA18 spata18 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SPATA18, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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