Western Blot (WB)
(Western blot analysis of JMJD1C in human liver tissue lysate with JMJD1C antibody at (A) 1 and (B) 2 μg/mL.)
Rabbit JMJD1C Polyclonal Antibody | anti-JMJD1C antibody
JMJD1C Antibody
Gene Names
JMJD1C; TRIP8
Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
Purity
JMJD1C Antibody is affinity chromatography purified via peptide column.
Synonyms
JMJD1C; Polyclonal Antibody; JMJD1C Antibody; TRIP8; JHDM2C; KIAA1380; Probable JmjC domain-containing histone demethylation protein 2C; Jumonji domain-containing protein 1C; TR-interacting protein 8; jumonji domain containing 1C; anti-JMJD1C antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
This antibody will not cross-react with JMJD1A or JMJD1B.
Purity/Purification
JMJD1C Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
2540
Applicable Applications for anti-JMJD1C antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes
JMJD1C antibody can be used for detection of JMJD1C by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
Conjugate
Unconjugated
Immunogen
JMJD1C antibody was raised against a 20 amino acid synthetic peptide from near the amino terminus of human JMJD1C.
Buffer
JMJD1C Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
JMJD1C antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Western Blot (WB)
(Western blot analysis of JMJD1C in human liver tissue lysate with JMJD1C antibody at (A) 1 and (B) 2 μg/mL.)
Western Blot (WB)
(Western blot analysis of JMJD1C in human liver tissue lysate with JMJD1C antibody at (A) 1 and (B) 2 μg/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of JMJD1C in rat liver tissue with JMJD1C antibody at 2.5 μg/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of JMJD1C in rat liver tissue with JMJD1C antibody at 2.5 μg/mL.)
Immunofluorescence (IF)
(Immunofluorescence of JMJD1C in rat liver tissue with JMJD1C antibody at 20 μg/mL.)
Immunofluorescence (IF)
(Immunofluorescence of JMJD1C in rat liver tissue with JMJD1C antibody at 20 μg/mL.)
Related Product Information for anti-JMJD1C antibody
JMJD1C Antibody: The jumonji domain containing 1C protein (JMJD1C) was initially discovered in silico, and later suggested to be a candidate gene for autism. Like the related proteins JMJD1A and JMJD1B, JMJD1C is a histone H3K9 demethylase implicated in the nuclear hormone receptor-based transcriptional regulation. JMJD1C mRNA is highly expressed in undifferentiated embryonic stem (ES) cells as well as pancreatic islet, diffuse-type gastric cancer, and other tissues and tumors. The JMJD1C gene promoter contain bHLH-, AP-1-, and POU5F1-binding sites, and as preferential expression of POU5F1 has been reported in ES cells, pancreatic islet, and diffuse-type gastric cancer, it has been suggested that POU5F1-mediated expression of JMJD1C reactivates previously silenced genes in ES cells and diffuse-type gastric cancer. At least three isoforms of JMJD1C are known to exist.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
263,157 Da
NCBI Official Full Name
probable JmjC domain-containing histone demethylation protein 2C isoform a
NCBI Official Synonym Full Names
jumonji domain containing 1C
NCBI Official Symbol
JMJD1C
NCBI Official Synonym Symbols
TRIP8
NCBI Protein Information
probable JmjC domain-containing histone demethylation protein 2C; TRIP-8; TR-interacting protein 8; jumonji domain-containing protein 1C; thyroid hormone receptor interactor 8; thyroid receptor interacting protein 8; thyroid receptor-interacting protein 8
UniProt Protein Name
Probable JmjC domain-containing histone demethylation protein 2C
UniProt Gene Name
JMJD1C
UniProt Synonym Gene Names
JHDM2C; KIAA1380; TRIP8; TR-interacting protein 8; TRIP-8
UniProt Entry Name
JHD2C_HUMAN
Uniprot Description
TRIP8: Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes. Belongs to the JHDM2 histone demethylase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription, coactivator/corepressor; EC 1.14.11.-; Oxidoreductase; Nuclear receptor co-regulator; Demethylase
Chromosomal Location of Human Ortholog: 10q21.3
Cellular Component: nucleoplasm; intracellular
Molecular Function: protein binding; dioxygenase activity; metal ion binding; thyroid hormone receptor binding
Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; chromatin modification; blood coagulation
Research Articles on JMJD1C
Similar Products
Product Notes
The JMJD1C jmjd1c (Catalog #AAA151278) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The JMJD1C Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's JMJD1C can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). JMJD1C antibody can be used for detection of JMJD1C by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL. Researchers should empirically determine the suitability of the JMJD1C jmjd1c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "JMJD1C, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
