Rabbit anti-Human, Mouse FAIM Polyclonal Antibody | anti-FAIM antibody

FAIM Antibody

Cat. Num. AAA150757

• Gene Names: FAIM; FAIM1
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot
• Purity: FAIM Antibody is affinity chromatography purified via peptide column.
• Synonyms: FAIM; Polyclonal Antibody; FAIM Antibody; FAIM1; Fas apoptotic inhibitory molecule 1; Fas apoptotic inhibitory molecule; anti-FAIM antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: FAIM Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Sequence Length: 179

• Applicable Applications for anti-FAIM antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: FAIM antibody can be used for detection of FAIM by Western blot at 5 - 10 mug/mL.
• Conjugate: Unconjugated
• Immunogen: FAIM antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human FAIM.
• Buffer: FAIM Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: FAIM antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of FAIM in human spleen tissue lysate with FAIM antibody at (A) 5 and (B) 10 μg/mL. )

Related Product Information for anti-FAIM antibody

FAIM Antibody: The susceptibility of primary splenic B cells to Fas-mediated apoptosis is regulated in a receptor-specific fashion. Terminal effectors of B cell Fas-resistance include the known anti-apoptotic proteins Bcl-xL, FLIP, and a recently identified protein termed FAIM. This molecule is broadly expressed in various tissues and exists in at least three isoforms. It is thought that resistance to Fas killing via increased expression of FAIM protects foreign antigen-specific B cells during interactions with FasL-bearing T cells whereas autoreactive B cells are deleted via Fas-dependent cytotoxicity. More recent results have indicated that FAIM interacts with both Trk and p75 neurotrophin receptor and may play a role in promoting neurite outgrowth in different neuronal systems by a mechanism involving the activation of NF-κB and the Ras-ERK pathway.

NCBI and Uniprot Product Information

• NCBI GI #: 8922536
• NCBI GeneID: 55179
• NCBI Accession #: NP_060617
• NCBI GenBank Nucleotide #: NM_018147.3
• UniProt Accession #: Q9NVQ4; Q6IAN2
• Molecular Weight: 22,626 Da
• NCBI Official Full Name: fas apoptotic inhibitory molecule 1 isoform c
• NCBI Official Synonym Full Names: Fas apoptotic inhibitory molecule
• NCBI Official Symbol: FAIM
• NCBI Official Synonym Symbols: FAIM1
• NCBI Protein Information: fas apoptotic inhibitory molecule 1
• UniProt Protein Name: Fas apoptotic inhibitory molecule 1
• Protein Family: Fas apoptotic inhibitory molecule
• UniProt Gene Name: FAIM
• UniProt Synonym Gene Names: FAIM1
• UniProt Entry Name: FAIM1_HUMAN

NCBI Description

The protein encoded by this gene protects against death receptor-triggered apoptosis and regulates B-cell signaling and differentiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

Uniprot Description

FAIM: Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells. Belongs to the FAIM1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 3q22.3

Cellular Component: cytoplasm

Biological Process: apoptosis; negative regulation of apoptosis