Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human colon cancer using MBS1499652 at dilution 1:100)
Rabbit anti-Human Huntingtin-interacting protein 1 Polyclonal Antibody | anti-HIP1 antibody
Rabbit anti-human Huntingtin-interacting protein 1 polyclonal Antibody(HIP1)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human colon cancer using MBS1499652 at dilution 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human colon cancer using MBS1499652 at dilution 1:100)
NCBI and Uniprot Product Information
NCBI Description
The product of this gene is a membrane-associated protein that functions in clathrin-mediated endocytosis and protein trafficking within the cell. The encoded protein binds to the huntingtin protein in the brain; this interaction is lost in Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Description
HIP1: Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors. A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB. The chimeric HIP1-PDGFRB transcript results from an in-frame fusion of the two genes. The reciprocal PDGFRB-HIP1 transcript is not expressed. Belongs to the SLA2 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis; Cytoskeletal
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component: clathrin coated vesicle membrane; clathrin-coated vesicle; cytoplasm; cytoskeleton; Golgi apparatus; intracellular membrane-bound organelle; membrane; nucleus
Molecular Function: actin binding; clathrin binding; phosphoinositide binding; protein binding; structural constituent of cytoskeleton
Biological Process: apoptosis; caspase activation; cell differentiation; clathrin cage assembly; positive regulation of receptor-mediated endocytosis; regulation of apoptosis; regulation of transcription, DNA-dependent; transcription, DNA-dependent
Disease: Prostate Cancer
Research Articles on HIP1
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Product Notes
The HIP1 hip1 (Catalog #AAA1499652) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human Huntingtin-interacting protein 1 polyclonal Antibody(HIP1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Huntingtin-interacting protein 1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). Recommended dilution: IHC:1:20-1:200. Researchers should empirically determine the suitability of the HIP1 hip1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Huntingtin-interacting protein 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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