Rabbit anti-Human 5-hydroxytryptamine receptor 2B Polyclonal Antibody | anti-PTGES3 antibody

Rabbit anti-human 5-hydroxytryptamine receptor 2B polyclonal Antibody(PTGES3)

Cat. Num. AAA1499219

• Gene Names: HTR2B; 5-HT2B; 5-HT(2B)
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen Affinity Purified
• Synonyms: 5-hydroxytryptamine receptor 2B; Polyclonal Antibody; Rabbit anti-human 5-hydroxytryptamine receptor 2B polyclonal Antibody(PTGES3); 5-HT-2B; 5-HT2B; Serotonin receptor 2B; HTR2B; anti-PTGES3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purified
• Sequence Length: 481

• Applicable Applications for anti-PTGES3 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: Recommended dilution: IHC:1:20-1:200
• Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Conjugate: Non-conjugated
• Immunogen: Recombinant human 5-hydroxytryptamine receptor 2B protein (382-481aa)
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-15076 / sc-15080 / sc-25647
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human prostate using MBS1499219 at dilution 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human lung using MBS1499219 at dilution 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human brain using MBS1499219 at dilution 1:100)

Related Product Information for anti-PTGES3 antibody

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca2+ ions from intracellular stores. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine.

NCBI and Uniprot Product Information

• NCBI GI #: 222080049
• NCBI GeneID: 3357
• NCBI Accession #: NP_000858.3
• NCBI GenBank Nucleotide #: NM_000867.4
• UniProt Accession #: P41595; Q53TI1; Q62221; Q6P523; B2R9D5; AAB31827
• Molecular Weight: 54,298 Da
• NCBI Official Full Name: 5-hydroxytryptamine receptor 2B
• NCBI Official Synonym Full Names: 5-hydroxytryptamine receptor 2B
• NCBI Official Symbol: HTR2B
• NCBI Official Synonym Symbols: 5-HT2B; 5-HT(2B)
• NCBI Protein Information: 5-hydroxytryptamine receptor 2B
• UniProt Protein Name: 5-hydroxytryptamine receptor 2B
• Protein Family: 5-hydroxytryptamine receptor
• UniProt Gene Name: HTR2B
• UniProt Synonym Gene Names: 5-HT-2B; 5-HT2B
• UniProt Entry Name: 5HT2B_HUMAN

NCBI Description

This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. [provided by RefSeq, Oct 2011]

Uniprot Description

5-HT(2B): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Plays a role in the regulation of impulsive behavior. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 2q36.3-q37.1

Cellular Component: cell junction; cell soma; cytoplasm; dendrite; integral to plasma membrane; plasma membrane; synapse

Molecular Function: drug binding; G-protein alpha-subunit binding; GTPase activator activity; serotonin binding; serotonin receptor activity

Biological Process: behavior; calcium-mediated signaling; cellular calcium ion homeostasis; cGMP biosynthetic process; embryonic morphogenesis; G-protein coupled receptor internalization; G-protein coupled receptor protein signaling pathway; heart morphogenesis; inositol phosphate metabolic process; intestine smooth muscle contraction; negative regulation of apoptosis; negative regulation of autophagy; neural crest cell differentiation; neural crest cell migration; phosphoinositide 3-kinase cascade; phospholipase C activation; phosphorylation; positive regulation of cell division; positive regulation of cell proliferation; positive regulation of cytokine production; positive regulation of cytokine secretion; positive regulation of endothelial cell proliferation; positive regulation of GTPase activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of MAP kinase activity; positive regulation of nitric-oxide synthase activity; positive regulation of phosphatidylinositol biosynthetic process; protein kinase C activation; regulation of behavior; release of sequestered calcium ion into cytosol; response to drug; serotonin receptor signaling pathway; vasoconstriction