Rabbit anti-Human DNA Polyclonal Antibody | anti-DNA antibody

Rabbit anti-human DNA ligase 1 polyclonal Antibody, Biotin conjugated

Cat. Num. AAA1490756

• Reactivity: Human
• Applications: ELISA
• Purity: Caprylic Acid Ammonium Sulfate Precipitation Purified
• Synonyms: DNA; Polyclonal Antibody; Rabbit anti-human DNA ligase 1 polyclonal Antibody; Biotin conjugated; DNA ligase I; Polydeoxyribonucleotide synthase [ATP] 1; LIG1; anti-DNA antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Caprylic Acid Ammonium Sulfate Precipitation Purified
• Sequence Length: 919

• Applicable Applications for anti-DNA antibody: ELISA (EIA)
• Storage Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugate: Biotin
• Immunogen: Recombinant human DNA ligase 1 protein
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-20222 / sc-20224 / sc-366180
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Related Product Information for anti-DNA antibody

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

NCBI and Uniprot Product Information

• NCBI GI #: 4557719
• NCBI GeneID: 3978
• NCBI Accession #: NP_000225.1
• NCBI GenBank Nucleotide #: NM_000234.2
• UniProt Accession #: P18858; Q2TB12; Q32P23; B2RAI8; B4DTU4
• Molecular Weight: 98,228 Da
• NCBI Official Full Name: DNA ligase 1 isoform 1
• NCBI Official Synonym Full Names: ligase I, DNA, ATP-dependent
• NCBI Official Symbol: LIG1
• NCBI Protein Information: DNA ligase 1
• UniProt Protein Name: DNA ligase 1
• Protein Family: DNA
• UniProt Gene Name: LIG1
• UniProt Entry Name: DNLI1_HUMAN

NCBI Description

This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Uniprot Description

LIG1: is an enzyme that functions in DNA replication and the base excision repair process. Mutations leading to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents.

Protein type: DNA repair, damage; Ligase; EC 6.5.1.1

Chromosomal Location of Human Ortholog: 19q13.2-q13.3

Cellular Component: Golgi apparatus; intracellular membrane-bound organelle; mitochondrion; nucleoplasm; nucleus

Molecular Function: ATP binding; DNA binding; DNA ligase (ATP) activity; DNA ligase activity; metal ion binding

Biological Process: anatomical structure morphogenesis; base-excision repair; cell division; DNA ligation; DNA ligation during DNA repair; DNA metabolic process; DNA repair; DNA strand elongation during DNA replication; double-strand break repair via nonhomologous end joining; mismatch repair; mitotic cell cycle; nucleotide-excision repair; nucleotide-excision repair, DNA gap filling; response to hydrogen peroxide; telomere maintenance; telomere maintenance via recombination; telomere maintenance via semi-conservative replication; transcription-coupled nucleotide-excision repair; V(D)J recombination