RAS guanyl-releasing protein 1 (Rasgrp1) Recombinant Protein | Rasgrp1 recombinant protein

Recombinant Rat RAS guanyl-releasing protein 1 (Rasgrp1)

Cat. Num. AAA1474297

• Gene Names: Rasgrp1; Rasgrp
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: RAS guanyl-releasing protein 1 (Rasgrp1); Recombinant Rat RAS guanyl-releasing protein 1 (Rasgrp1); Rasgrp1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-795, full length protein
• Sequence: MGTLGKAREAPRKPCHGSRAGPKGRLEAKSTNSPLPAQPSLAQITQFRMMVSLGHLAKGASLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIIISSAELLQKLMNLYKDALEKNSPGICLKICYFVRYWITEFWIMFKMDASLTSTMEEFQDLVKANGEESHCHLIDTTQINSRDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIHVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSCRNYDNYRRAYGECTHFKIPILGVHLKDLISLYEAMPDYLEDGKVNVQKLLALYNHINELVQLQDVAPPLDANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVFKNYDLDQDGYISQEEFEKIAASFPFSFCVMDKDREGLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKRSKSPAVSTENISSVVPMSTLCPLGTKDLLHAPEEGSFIFQNGEVVDHSEESKDRTIMLLGVSSQKISVRLKRTVAHKTTQTESFPWVGGEMPPGHFVLTSPRKSAQGALYVHSPASPCPSPALVRKRAFVKWENKESLIKPKPELHLRLRTYQELEQEVNTLRADNDALKIQLKYAQKQIESLQLGKSNHVLAQMDHGDGT
• Sequence Length: 795

• Species: Rat
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Rasgrp1 recombinant protein

This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk
MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE).

NCBI and Uniprot Product Information

• NCBI GI #: 31377530
• NCBI GeneID: 29434
• NCBI Accession #: NP_062084.2
• NCBI GenBank Nucleotide #: NM_019211.2
• UniProt Accession #: Q9R1K8; O88469
• Molecular Weight: 90,245 Da
• NCBI Official Full Name: RAS guanyl-releasing protein 1
• NCBI Official Synonym Full Names: RAS guanyl releasing protein 1
• NCBI Official Symbol: Rasgrp1
• NCBI Official Synonym Symbols: Rasgrp
• NCBI Protein Information: RAS guanyl-releasing protein 1
• UniProt Protein Name: RAS guanyl-releasing protein 1
• Protein Family: RAS guanyl-releasing protein
• UniProt Gene Name: Rasgrp1
• UniProt Synonym Gene Names: Rasgrp; CalDAG-GEFII

NCBI Description

putative guanine nucleotide exchange factor with Ca2+ and diacylglycerol binding domains; may activate Rap protein mediated inhibition of Ras signaling pathways [RGD, Feb 2006]

Uniprot Description

Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:9789079, PubMed:9582122). Activates the Erk/MAP kinase cascade. Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras. Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types. Proto-oncogene, which promotes T-cell lymphomagenesis when its expression is deregulated ().