Nuclear receptor subfamily 0 group B member 2 (Nr0b2) Recombinant Protein | Nr0b2 recombinant protein

Recombinant Mouse Nuclear receptor subfamily 0 group B member 2 (Nr0b2)

Cat. Num. AAA1469816

• Gene Names: Nr0b2; SHP; Shp1; SHP-1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Nuclear receptor subfamily 0 group B member 2 (Nr0b2); Recombinant Mouse Nuclear receptor subfamily 0 group B member 2 (Nr0b2); Nr0b2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-260, full length protein
• Sequence: MSSGQSGVCPCQGSAGRPTILYALLSPSPRTRPVAPASHSHCLCQQQRPVRLCAPHRTCREALDVLAKTVAFLRNLPSFCHLPHEDQRRLLECCWGPLFLLGLAQDAVTFEVAEAPVPSILKKILLEEASSGTQGAQPSDRPQPSLAAVQWLQRCLESFWSLELGPKEYAYLKGTILFNPDVPGLRASCHIAHLQQEAHWALCEVLEPWYPASQGRLARILLMASTLKNIPGTLLVDLFFRPIMGDVDITELLEDMLLLR
• Sequence Length: 260

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Nr0b2 recombinant protein

This protein is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.

NCBI and Uniprot Product Information

• NCBI GI #: 6754886
• NCBI GeneID: 23957
• NCBI Accession #: NP_035980.1
• NCBI GenBank Nucleotide #: NM_011850.3
• UniProt Accession #: Q62227; Q53Z53
• Molecular Weight: 28,763 Da
• NCBI Official Full Name: nuclear receptor subfamily 0 group B member 2
• NCBI Official Synonym Full Names: nuclear receptor subfamily 0, group B, member 2
• NCBI Official Symbol: Nr0b2
• NCBI Official Synonym Symbols: SHP; Shp1; SHP-1
• NCBI Protein Information: nuclear receptor subfamily 0 group B member 2
• UniProt Protein Name: Nuclear receptor subfamily 0 group B member 2
• Protein Family: Nuclear receptor subfamily
• UniProt Gene Name: Nr0b2
• UniProt Synonym Gene Names: Shp

NCBI Description

This gene encodes a member of the nuclear hormone receptor family of proteins. The encoded orphan receptor lacks a DNA binding domain but modulates gene expression by interacting with other hormone receptors to competitively inhibit binding of coactivators while also acting as a transcriptional corepressor. The encoded receptor may regulate bile acid synthesis and sexual maturation in males. Homozygous knockout mice exhibit accumulation of bile acids, reduced levels of low density lipoprotein cholesterol (LDL-C), and in male mice, earlier testicular maturation. [provided by RefSeq, Aug 2015]

Uniprot Description

Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1.