Heterogeneous Nuclear Ribonucleoprotein A/B Recombinant Protein | HNRNPAB recombinant protein

Recombinant Human Heterogeneous Nuclear Ribonucleoprotein A/B

Cat. Num. AAA146428

• Gene Names: HNRNPAB; ABBP1; HNRPAB
• Purity: Greater than 95.0% as determined by SDS-PAGE.
• Synonyms: Heterogeneous Nuclear Ribonucleoprotein A/B; Recombinant Human Heterogeneous Nuclear Ribonucleoprotein A/B; HNRNPAB Human; Heterogeneous Nuclear Ribonucleoprotein A/B Human Recombinant; ABBP-1; ABBP1; APOBEC1-Binding Protein 1; HnRNP A/B; Apobec-1 Binding Protein 1; Apolipoprotein B MRNA Editing Enzyme; Catalytic Polypeptide 1-Binding Protein 1; HnRNP Type A/B Protein; HNRNPAB recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 95.0% as determined by SDS-PAGE.
• Form/Format: HNRNPAB protein solution (0.25mg/ml) containing 30% glycerol and 1mM DTT.; Sterile Filtered clear solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSMSEAGEE QPMETTGATE NGHEAVPEGE SPAGAGTGAA AGAGGATAAP PSGNQNGAEGDQINASKNEE DAGKMFVGGL SWDTSKKDLK DYFTKFGEVV DCTIKMDPNT GRSRGFGFIL FKDAASVEKVLDQKEHRLDG RVIDPKKAMA MKKDPVKKIF VGGLNPEATE EKIREYFGEF GEIEAIELPM DPKLNKRRGF VFITFKEEEPVKKVLEKKFH TVSGSKCEIK VAQPKEVYQQ QQYGSGGRGN RNRGNRGSGG GGGGGGQGST NYGKSQRRGGHQNNYKPY
• Sequence Length: 285

Related Product Information for HNRNPAB recombinant protein

Description: HNRNPAB Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 308 amino acids (1-285 a.a) and having a molecular mass of 33kDa.HNRNPAB is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: Heterogeneous Nuclear Ribonucleoprotein A/B (HNRNPAB) is a member of the subfamily of ubiquitously expressed heterogeneous

Product Categories/Family for HNRNPAB recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; Heterogeneous Nuclear Ribonucleoprotein

NCBI and Uniprot Product Information

• NCBI GI #: 55956921
• NCBI GeneID: 3182
• NCBI Accession #: NP_004490.2
• NCBI GenBank Nucleotide #: NM_004499.3
• UniProt Accession #: Q99729; Q04150; Q8N7U3; Q9BQ99; B3KNN5; D3DWP7
• Molecular Weight: 30,701 Da
• NCBI Official Full Name: heterogeneous nuclear ribonucleoprotein A/B isoform b
• NCBI Official Synonym Full Names: heterogeneous nuclear ribonucleoprotein A/B
• NCBI Official Symbol: HNRNPAB
• NCBI Official Synonym Symbols: ABBP1; HNRPAB
• NCBI Protein Information: heterogeneous nuclear ribonucleoprotein A/B; ABBP-1; APOBEC1-binding protein 1; apobec-1 binding protein 1; apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1-binding protein 1; hnRNP A/B; hnRNP type A/B protein
• UniProt Protein Name: Heterogeneous nuclear ribonucleoprotein A/B
• Protein Family: Heterogeneous nuclear ribonucleoprotein
• UniProt Gene Name: HNRNPAB
• UniProt Synonym Gene Names: ABBP1; HNRPAB; hnRNP A/B; ABBP-1
• UniProt Entry Name: ROAA_HUMAN

NCBI Description

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

hnRNP A/B: a single-stranded RNA binding protein with two RNA-recognition (RRM) domains. Has a high affinity for G- rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site. Interacts with APOBEC1. Observed in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. A member of the RNA recognition motif (RRM) family. Four isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 5q35.3

Cellular Component: nucleoplasm; cytoplasm; ribonucleoprotein complex; nucleus

Molecular Function: mRNA binding; sequence-specific DNA binding; RNA binding; nucleotide binding; transcription factor activity

Biological Process: positive regulation of transcription, DNA-dependent; epithelial to mesenchymal transition; negative regulation of transcription from RNA polymerase II promoter