Polymerase, Epsilon 3 Recombinant Protein | POLE3 recombinant protein
Recombinant Human Polymerase (DNA Directed), Epsilon 3
Gene Names
POLE3; p17; YBL1; CHRAC17; CHARAC17
Purity
Greater than 90.0% as determined by SDS-PAGE.
Synonyms
Polymerase; Epsilon 3; Recombinant Human Polymerase (DNA Directed); POLE3 Human; Polymerase (DNA Directed); Epsilon 3 Human Recombinant; CHARAC17; CHRAC17; p17; YBL1; DNA polymerase epsilon subunit 3; Arsenic-transactivated protein; AsTP; Chromatin accessibility complex 17 kDa protein; HuCHRAC17; DNA polymerase II subunit 3; DNA polymerase epsilon subunit p17; POLE3; POLE3 recombinant protein
Host
E Coli
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Form/Format
The POLE3 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 20% glycerol and 1mM DTT.
Sterile Filtered clear solution.
Sterile Filtered clear solution.
Sequence
MGSSHHHHHH SSGLVPRGSH MGSMAERPED LNLPNAVITR IIKEALPDGV NISKEARSAI SRAASVFVLY ATSCANNFAM KGKRKTLNAS DVLSAMEEME FQRFVTPLKE ALEAYRREQK GKKEASEQKK KDKDKKTDSE EQDKSRDEDN DEDEERLEEE EQNEEEEVDN
Sequence Length
147
Related Product Information for POLE3 recombinant protein
Description: POLE3 Human Recombinant produced in E Coli is a single polypeptide chain containing 170 amino acids (1-147) and having a molecular mass of 19kDa. POLE3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction: Polymerase (DNA Directed), Epsilon 3, also know as POLE3, is a histone-fold protein which interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers merge into larger enzymatic complexes for DNA transcription, replication, and packaging.
Introduction: Polymerase (DNA Directed), Epsilon 3, also know as POLE3, is a histone-fold protein which interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers merge into larger enzymatic complexes for DNA transcription, replication, and packaging.
Product Categories/Family for POLE3 recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
16,860 Da
NCBI Official Full Name
DNA polymerase epsilon subunit 3
NCBI Official Synonym Full Names
polymerase (DNA directed), epsilon 3, accessory subunit
NCBI Official Symbol
POLE3
NCBI Official Synonym Symbols
p17; YBL1; CHRAC17; CHARAC17
NCBI Protein Information
DNA polymerase epsilon subunit 3; CHRAC-17; DNA polymerase II subunit 3; DNA polymerase epsilon p17 subunit; DNA polymerase epsilon subunit p17; arsenic transactivated protein; arsenic-transactivated protein; asTP; chromatin accessibility complex 17 kDa protein; histone fold protein CHRAC17; huCHRAC17; polymerase (DNA directed), epsilon 3 (p17 subunit)
UniProt Protein Name
DNA polymerase epsilon subunit 3
Protein Family
UniProt Gene Name
POLE3
UniProt Synonym Gene Names
CHRAC17; AsTP; CHRAC-17; HuCHRAC17
UniProt Entry Name
DPOE3_HUMAN
NCBI Description
POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]
Uniprot Description
POLE3: Forms a complex with DNA polymerase epsilon subunit CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1.
Protein type: EC 2.7.7.7; DNA replication; Nucleotide Metabolism - purine; Transferase; Nucleotide Metabolism - pyrimidine
Chromosomal Location of Human Ortholog: 9q33
Cellular Component: epsilon DNA polymerase complex; nucleus
Molecular Function: protein binding; protein heterodimerization activity; sequence-specific DNA binding; DNA-directed DNA polymerase activity
Biological Process: DNA replication
