GTPase, IMAP Family Member 5 Recombinant Protein | GIMAP5 recombinant protein
Recombinant Human GTPase, IMAP Family Member 5
Gene Names
GIMAP5; IAN4; IAN5; IROD; IAN-5; IMAP3; HIMAP3; IAN4L1
Purity
Greater than 85.0% as determined by SDS-PAGE.
Synonyms
GTPase; IMAP Family Member 5; Recombinant Human GTPase; GIMAP5 Human; IMAP Family Member 5 Human Recombinant; GTPase IMAP family member 5; Immunity-associated nucleotide 4-like 1 protein; Immunity-associated nucleotide 5 protein; IAN-5; hIAN5; Immunity-associated protein 3; GIMAP5; IAN4L1; IAN5; IMAP3; HIMAP3; IAN4; IROD; GIMAP5 recombinant protein
Host
E Coli
Purity/Purification
Greater than 85.0% as determined by SDS-PAGE.
Form/Format
The GIMAP5 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 40% glycerol and 2mM DTT.
Sterile Filtered colorless solution.
Sterile Filtered colorless solution.
Sequence
MGSSHHHHHH SSGLVPRGSH MGSMGGFQRG KYGTMAEGRS EDNLSATPPA LRIILVGKTG CGKSATGNSI LGQPVFESKL RAQSVTRTCQ VKTGTWNGRK VLVVDTPSIF ESQADTQELY KNIGDCYLLS APGPHVLLLV IQLGRFTAQD TVAIRKVKEV FGTGAMRHVV ILFTHKEDLG GQALDDYVAN TDNCSLKDLV RECERRYCAF NNWGSVEEQR QQQAELLAVI ERLGREREGS FHSNDLFLDA QLLQRTGAGA CQEDYRQYQA KVEWQVEKHK QELRENESNW AYKALLRVKH LMLLHYE.
Sequence Length
307
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Related Product Information for GIMAP5 recombinant protein
Description: GIMAP5 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 307 amino acids (1-284) and having a molecular mass of 34.4 kDa.GIMAP5 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction: GTPase, IMAP Family Member 5 (GIMAP5) is a part of the GTP-binding superfamily and the immuno-associated nucleotide subfamily of nucleotide-binding proteins. GIMAP5 is an antiapoptotic protein which is required for mitochondrial integrity and T-cell survival. Polymorphisms in GIMAP5 are related with systemic lupus erythematosus. Read-through transcription can be found between GIMAP5 and the neighboring upstream GIMAP1 (GTPase, IMAP family member 1) gene. GIMAP5 also contributes to T-cell quiescence.
Introduction: GTPase, IMAP Family Member 5 (GIMAP5) is a part of the GTP-binding superfamily and the immuno-associated nucleotide subfamily of nucleotide-binding proteins. GIMAP5 is an antiapoptotic protein which is required for mitochondrial integrity and T-cell survival. Polymorphisms in GIMAP5 are related with systemic lupus erythematosus. Read-through transcription can be found between GIMAP5 and the neighboring upstream GIMAP1 (GTPase, IMAP family member 1) gene. GIMAP5 also contributes to T-cell quiescence.
Product Categories/Family for GIMAP5 recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
39,584 Da
NCBI Official Full Name
GTPase IMAP family member 5
NCBI Official Synonym Full Names
GTPase, IMAP family member 5
NCBI Official Symbol
GIMAP5
NCBI Official Synonym Symbols
IAN4; IAN5; IROD; IAN-5; IMAP3; HIMAP3; IAN4L1
NCBI Protein Information
GTPase IMAP family member 5; immune associated nucleotide 4 like 1; immune-associated nucleotide-binding protein 5; immunity associated protein 3; immunity-associated nucleotide 5 protein; inhibitor of radiation- and OA-induced apoptosis, Irod/Ian5
UniProt Protein Name
GTPase IMAP family member 5
Protein Family
UniProt Gene Name
GIMAP5
UniProt Synonym Gene Names
IAN4L1; IAN5; IMAP3; IAN-5; hIAN5
UniProt Entry Name
GIMA5_HUMAN
NCBI Description
This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene encodes an antiapoptotic protein that functions in T-cell survival. Polymorphisms in this gene are associated with systemic lupus erythematosus. Read-through transcription exists between this gene and the neighboring upstream GIMAP1 (GTPase, IMAP family member 1) gene. [provided by RefSeq, Dec 2010]
Uniprot Description
GIMAP5: Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence. Belongs to the IAN GTP-binding protein family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis; Hydrolase; Membrane protein, integral; Mitochondrial
Chromosomal Location of Human Ortholog: 7q36.1
Cellular Component: mitochondrial outer membrane; lysosome; integral to membrane
Molecular Function: GTP binding
Research Articles on GIMAP5
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Product Notes
The GIMAP5 gimap5 (Catalog #AAA146288) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: MGSSHHH HHH SSGLVPRGSH MGSMGG FQRG KYGTMAEGRS EDNLSATPPA LRIILVGKTG CGKSATGNSI LGQPVFESKL RAQSVTRTCQ VKTGTWNGRK VLVVDTPSIF ESQADTQELY KNIGDCYLLS APGPHVLLLV IQLGRFTAQD TVAIRKVKEV FGTGAMRHVV ILFTHKEDLG GQALDDYVAN TDNCSLKDLV RECERRYCAF NNWGSVEEQR QQQAELLAVI ERLGREREGS FHSNDLFLDA QLLQRTGAGA CQEDYRQYQA KVEWQVEKHK QELRENESNW AYKALLRVKH LMLLHYE.. It is sometimes possible for the material contained within the vial of "GTPase, IMAP Family Member 5, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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