Ankyrin Repeat Domain 1 Recombinant Protein | ANKRD1 recombinant protein

Recombinant Human Ankyrin Repeat Domain 1

Cat. Num. AAA146182

• Gene Names: ANKRD1; ALRP; CARP; C-193; CVARP; MCARP; bA320F15.2
• Purity: Greater than 85% as determined by SDS-PAGE.
• Synonyms: Ankyrin Repeat Domain 1; Recombinant Human Ankyrin Repeat Domain 1; ANKRD1 Human; Ankyrin Repeat Domain 1 Human Recombinant; Ankyrin Repeat Domain 1 (Cardiac Muscle); Cardiac Ankyrin Repeat Protein; Cytokine-Inducible Gene C-193 Protein; Ankyrin Repeat Domain-Containing Protein 1; Cytokine-Inducible Nuclear Protein; Liver Ankyrin Repeat Domain 1; BA320F15.2; CARP; ALRP; CVARP; MCARP; HA1A2; C193; ANKRD1 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 85% as determined by SDS-PAGE.
• Form/Format: The ANKRD1 solution contains 20mM Tris-HCl buffer (pH 8.5), 0.2M NaCl, 5mM DTT and 50% glycerol.; Sterile Filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MGS MMVLKVE ELVTGKKNGN GEAGEFLPED FRDGEYEAAV TLEKQEDLKT LLAHPVTLGE QQWKSEKQRE AELKKKKLEQ RSKLENLEDL EIIIQLKKRK KYRKTKVPVV KEPEPEIITE PVDVPTFLKA ALENKLPVVE KFLSDKNNPD VCDEYKRTAL HRACLEGHLA IVEKLMEAGA QIEFRDMLES TAIHWASRGG NLDVLKLLLN KGAKISARDK LLSTALHVAV RTGHYECAEH LIACEADLNA KDREGDTPLH DAVRLNRYKM IRLLIMYGAD LNIKNCAGKT PMDLVLHWQN GTKAIFDSLR ENSYKTSRIA TF
• Sequence Length: 319

Related Product Information for ANKRD1 recombinant protein

Description: ANKRD1 Human Recombinant produced in E Coli is a single polypeptide chain containing 342 amino acids (1-319) and having a molecular mass of 38.6 kDa.ANKRD1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: ANKRD1 takes part in endothelial cell activation and performs as a nuclear transcription factor which negatively controls the expression of cardiac genes.

Product Categories/Family for ANKRD1 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 38327522
• NCBI GeneID: 27063
• NCBI Accession #: NP_055206.2
• NCBI GenBank Nucleotide #: NM_014391.2
• UniProt Accession #: Q15327; Q96LE7
• Molecular Weight: 36,252 Da
• NCBI Official Full Name: ankyrin repeat domain-containing protein 1
• NCBI Official Synonym Full Names: ankyrin repeat domain 1 (cardiac muscle)
• NCBI Official Symbol: ANKRD1
• NCBI Official Synonym Symbols: ALRP; CARP; C-193; CVARP; MCARP; bA320F15.2
• NCBI Protein Information: ankyrin repeat domain-containing protein 1; cardiac ankyrin repeat protein; cytokine-inducible gene C-193 protein; cytokine-inducible nuclear protein; liver ankyrin repeat domain 1
• UniProt Protein Name: Ankyrin repeat domain-containing protein 1
• Protein Family: Ankyrin repeat domain-containing protein
• UniProt Gene Name: ANKRD1
• UniProt Synonym Gene Names: C193; CARP; HA1A2
• UniProt Entry Name: ANKR1_HUMAN

NCBI Description

The protein encoded by this gene is localized to the nucleus of endothelial cells and is induced by IL-1 and TNF-alpha stimulation. Studies in rat cardiomyocytes suggest that this gene functions as a transcription factor. Interactions between this protein and the sarcomeric proteins myopalladin and titin suggest that it may also be involved in the myofibrillar stretch-sensor system. [provided by RefSeq, Jul 2008]

Uniprot Description

ANKRD1: May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells. Defects in ANKRD1 may be a cause of total anomalous pulmonary venous return (TAPVR). TAPVR is a rare congenital heart disease (CHD) in which the pulmonary veins fail to connect to the left atrium during cardiac development, draining instead into either the right atrium or one of its venous tributaries. This disease accounts for 1.5% of all CHDs and has a prevalence of approximately 1 out of 15'000 live births.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 10q23.31

Cellular Component: nucleoplasm; I band; transcription factor complex; sarcomere; cytoplasm; nucleolus; cytosol; nucleus

Molecular Function: protein binding; DNA binding; p53 binding; histone deacetylase binding; titin binding; transcription corepressor activity

Biological Process: positive regulation of protein secretion; positive regulation of apoptosis; cardiac muscle morphogensis; positive regulation of transcription from RNA polymerase II promoter; cellular lipid metabolic process; negative regulation of transcription from RNA polymerase II promoter; positive regulation of DNA damage response, signal transduction by p53 class mediator; sarcomere organization