PDZ Domain Containing 1 Recombinant Protein | PDZK1 recombinant protein

Recombinant Human PDZ Domain Containing 1

Cat. Num. AAA145590

• Gene Names: PDZK1; CAP70; CLAMP; PDZD1; NHERF3; NHERF-3
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: PDZ Domain Containing 1; Recombinant Human PDZ Domain Containing 1; PDZK1 Human; PDZ Domain Containing 1 Human Recombinant; PDZ-Containing Kidney Protein 1; Na(+)/H(+) Exchange Regulatory Cofactor NHE-RF3; Na/Pi Cotransporter C-Terminal-Associated Protein 1; Sodium-Hydrogen Exchanger Regulatory Factor 3; CFTR-Associated Protein Of 70 KDa; NHERF-3; CAP70; PDZD1; CLAMP; naPi-Cap1; PDZK1 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: PDZK1 protein solution (1mg/ml) contains 20mM Tris-HCl buffer, (pH 8.0), 0.1M NaCl, 0% glycerol and 1mM DTT.; Sterile Filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSMTSTFNP RECKLSKQEG QNYGFFLRIE KDTEGHLVRV VEKCSPAEKA GLQDGDRVLR INGVFVDKEE HMQVVDLVRK SGNSVTLLVL DGDSYEKAVK TRVDLKELGQ SQKEQGLSDN ILSPVMNGGV QTWTQPRLCY LVKEGGSYGF SLKTVQGKKG VYMTDITPQG VAMRAGVLAD DHLIEVNGEN VEDASHEEVV EKVKKSGSRV MFLLVDKETD KRHVEQKIQF KRETASLKLL PHQPRIVEMK KGSNGYGFYL RAGSEQKGQI IKDIDSGSPA EEAGLKNNDL VVAVNGESVE TLDHDSVVEM IRKGGDQTSL LVVDKETDNM YRLAHFSPFL YYQSQELPNG SVKEAPAPTP TSLEVSSPPD TTEEVDHKPK LCRLAKGENG YGFHLNAIRG LPGSFIKEVQ KGGPADLAGL EDEDVIIEVN GVNVLDEPYE KVVDRIQSSG KNVTLLVCGK KAYDYFQAKK IPIVSSLADP LDTPPDSKEG IVVESNHDSH MAKERAHSTA SHSSSNSEDT EM
• Sequence Length: 519

Related Product Information for PDZK1 recombinant protein

Description: PDZK1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 542 amino acids (1-519 a.a.) and having a molecular mass of 59.0kDa.PDZK1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: PDZK1 is a PDZ domain-containing scaffolding protein which facilitates localization of cell surface proteins and has a key part in cholesterol metabolism by regulating the HDL receptor, scavenger receptor class B type 1. Single nucleotide polymorphism in this gene is linked to metabolic syndrome, and overexpression results in drug resistance of multiple myeloma.

Product Categories/Family for PDZK1 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 318037203
• NCBI GeneID: 5174
• NCBI Accession #: NP_001188254.1
• NCBI GenBank Nucleotide #: NM_001201325.1
• UniProt Accession #: Q5T2W1; O60450; Q5T5P6; Q9BQ41; B4DPB9; E7EU02
• Molecular Weight: 44,665 Da
• NCBI Official Full Name: Na(+)/H(+) exchange regulatory cofactor NHE-RF3 isoform 1
• NCBI Official Synonym Full Names: PDZ domain containing 1
• NCBI Official Symbol: PDZK1
• NCBI Official Synonym Symbols: CAP70; CLAMP; PDZD1; NHERF3; NHERF-3
• NCBI Protein Information: Na(+)/H(+) exchange regulatory cofactor NHE-RF3; Na(+)/H(+) exchange regulatory cofactor NHE-RF3; CFTR-associated protein of 70 kDa; PDZ-containing kidney protein 1; na/Pi cotransporter C-terminal-associated protein 1; naPi-Cap1; sodium-hydrogen exchanger regulatory factor 3
• UniProt Protein Name: Na(+)/H(+) exchange regulatory cofactor NHE-RF3
• Protein Family: Na(+)/H(+) exchange regulatory cofactor
• UniProt Gene Name: PDZK1
• UniProt Synonym Gene Names: CAP70; NHERF3; PDZD1; NHERF-3; NaPi-Cap1
• UniProt Entry Name: NHRF3_HUMAN

NCBI Description

This gene encodes a PDZ domain-containing scaffolding protein. PDZ domain-containing molecules bind to and mediate the subcellular localization of target proteins. The encoded protein mediates the localization of cell surface proteins and plays a critical role in cholesterol metabolism by regulating the HDL receptor, scavenger receptor class B type 1. Single nucleotide polymorphisms in this gene may be associated with metabolic syndrome, and overexpression of this gene may play a role in drug resistance of multiple myeloma. Pseudogenes of this gene are located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Uniprot Description

PDZK1: A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. May function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function. Belongs to the NHER family.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: microvillus membrane; brush border membrane; apical plasma membrane; cytoplasm; plasma membrane; lipid raft

Molecular Function: protein binding; scavenger receptor binding; transporter activity; protein complex binding; PDZ domain binding

Biological Process: cell proliferation; drug transport; transport; carnitine transport