Methionine Sulfoxide Reductase B3 Recombinant Protein | MSRB3 recombinant protein
Recombinant Human Methionine Sulfoxide Reductase B3
Sterile Filtered colorless solution.
Introduction: Methionine sulfoxide reductase B3 (MSRB3) is a member of the methionine sulfoxide reductases (MSR) family proteins. MSRB3 catalyzes the reduction of methionine sulfoxide to methionine. The MSRB3 enzyme acts as a monomer and requires zinc as a cofactor. MSRs are thought to defend against reactive oxygen species-induced oxidative damage in various organs, including the most environmentally exposed organ, the human skin. MSRB3 has a vital role in cold tolerance by eliminating MetO and ROS which accumulate at the ER during cold acclimation.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene catalyzes the reduction of methionine sulfoxide to methionine. This enzyme acts as a monomer and requires zinc as a cofactor. Several transcript variants encoding two different isoforms have been found for this gene. One of the isoforms localizes to mitochondria while the other localizes to endoplasmic reticula. [provided by RefSeq, Jul 2010]
Uniprot Description
MSRB3: Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing. Defects in MSRB3 are the cause of deafness autosomal recessive type 74 (DFNB74). A form of non-syndromic sensorineural deafness characterized by prelingual, bilateral, profound hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. A nonsense mutation affecting exclusively mitochondrial isoform 2 is sufficient to produce hearing loss. Belongs to the MsrB Met sulfoxide reductase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Mitochondrial; EC 1.8.4.-; Oxidoreductase; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 12q14.3
Cellular Component: mitochondrion; endoplasmic reticulum
Molecular Function: zinc ion binding; peptide-methionine (R)-S-oxide reductase activity
Biological Process: protein repair; response to oxidative stress
Disease: Deafness, Autosomal Recessive 74
Research Articles on MSRB3
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Product Notes
The MSRB3 msrb3 (Catalog #AAA145382) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: MCGLPSGSCR DKKNCKVVFS QQELRKRLTP LQYHVTQEKG TESAFEGEYT HHKDPGIYKC VVCGTPLFKS ETKFDSGSGW PSFHDVINSE AITFTDDFSY GMHRVETSCS QCGAHLGHIF DDGPRPTGKR YCINSAALSF TPADSSGTAE GGSGVASPAQ ADKAELL EHH HHHH.. It is sometimes possible for the material contained within the vial of "Methionine Sulfoxide Reductase B3, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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