Adenylate Kinase 4 Recombinant Protein | AK4 recombinant protein

Recombinant Human Adenylate Kinase 4

Cat. Num. AAA145168

• Gene Names: AK4; AK3; AK 4; AK3L1; AK3L2
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Adenylate Kinase 4; Recombinant Human Adenylate Kinase 4; AK4 Human; Adenylate Kinase 4 Human Recombinant; AK3; Adenylate Kinase 3-like 1; AK3L1; ATP-AMP transphosphorylase; Adenylate Kinase 3; GTP:AMP phosphotransferase; mitochondrial adenylate kinase-3; AK3L2; MGC166959; EC 2.7.4.3; AK4 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: AK4 Human solution (1mg/1ml) containing 20mM Trsi HCL pH-8, 2mM DTT, 0.1M NaCl, and 10% glycerol.; Sterile filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MASKLLRAVI LGPPGSGKGT VCQRIAQNFG LQHLSSGHFL RENIKASTEV GEMAKQYIEK SLLVPDHVIT RLMMSELENR RGQHWLLDGF PRTLGQAEAL DKICEVDLVI SLNIPFETLK DRLSRRWIHP PSGRVYNLDF NPPHVHGIDD VTGEPLVQQE DDKPEAVAAR LRQYKDVAKP VIELYKSRGV LHQFSGTETN KIWPYVYTLF SNKITPIQSK EAY
• Sequence Length: 223

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Related Product Information for AK4 recombinant protein

Description: AK4 Human Recombinant produced in E Coli is a single, non-glycosylated,polypeptide chain containing 243 amino acids (1-223a.a.) and having a molecular mass of 27.4kDa. AK4 protein is fused to a 20 amino acid His tag at N-terminus and is purified by standard chromatography.

Introduction: AK4 belongs to the adenylate kinase family of enzymes. AK4 protein is restricted to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide structures in a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Hereditary mutations which cause AK4 deficiencies in erythrocytes have been associated to hemolytic anemia.

Product Categories/Family for AK4 recombinant protein

Protein Kinases; Enzymes; Adenylate Kinase

NCBI and Uniprot Product Information

• NCBI GI #: 53832003
• NCBI GeneID: 205
• NCBI Accession #: NP_001005353.1
• NCBI GenBank Nucleotide #: NM_001005353.2
• UniProt Accession #: P27144; Q6IBH4; Q6NXQ5; Q8IUU9; B2R927; D3DQ62
• Molecular Weight: 25,268 Da
• NCBI Official Full Name: adenylate kinase 4, mitochondrial
• NCBI Official Synonym Full Names: adenylate kinase 4
• NCBI Official Symbol: AK4
• NCBI Official Synonym Symbols: AK3; AK 4; AK3L1; AK3L2
• NCBI Protein Information: adenylate kinase 4, mitochondrial; AK 4; AK4; ATP-AMP transphosphorylase; GTP:AMP phosphotransferase AK4, mitochondrial; adenylate kinase 3-like 1; adenylate kinase isoenzyme 4, mitochondrial; mitochondrial adenylate kinase-3; nucleoside-triphosphate-adenylate kinase
• UniProt Protein Name: Adenylate kinase 4, mitochondrial
• Protein Family: Adenylate kinase
• UniProt Gene Name: AK4
• UniProt Entry Name: KAD4_HUMAN

NCBI Description

This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1. [provided by RefSeq, Jul 2008]

Uniprot Description

AK3L1: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. May also be active with GTP. Belongs to the adenylate kinase family.

Protein type: EC 2.7.4.10; Nucleotide Metabolism - purine; Kinase, other; EC 2.7.4.6; Mitochondrial

Chromosomal Location of Human Ortholog: 1p31.3

Cellular Component: mitochondrion; mitochondrial matrix

Molecular Function: GTP binding; nucleoside diphosphate kinase activity; adenylate kinase activity; nucleoside triphosphate adenylate kinase activity; ATP binding

Biological Process: ATP metabolic process; response to drug; nucleoside triphosphate biosynthetic process; ADP biosynthetic process; nucleoside diphosphate phosphorylation; brain development; liver development; AMP metabolic process; GTP metabolic process