GRO-gamma Active Protein | rGRO g/CINC-2a active protein
Recombinant Rat GRO-gamma (CXCL3), CINC-2 alpha
Sterile Filtered White lyophilized (freeze-dried) powder.
Introduction: Chemokine (C-X-C motif) ligand 3 (CXCL3) is a small cytokine belonging to the CXC chemokine family that is also known as GRO3 oncogene (GRO3), GRO protein gamma (GROg) and macrophage inflammatory protein-2-beta (MIP2b). CXCL3 controls migration and adhesion of monocytes and mediates it effects on its target cell by interacting with a cell surface chemokine receptor called CXCR2. The gene for CXCL3 is located on chromosome 4 in a cluster of other CXC chemokines.
NCBI and Uniprot Product Information
NCBI Description
acts as a chemoattractant for neutrophils; involved in the inflammatory response [RGD, Feb 2006]
Uniprot Description
CXCL1: Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO- alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity. Belongs to the intercrine alpha (chemokine CxC) family.
Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide
Cellular Component: extracellular space; extracellular region
Molecular Function: chemokine activity; CXCR chemokine receptor binding
Biological Process: G-protein coupled receptor protein signaling pathway; neutrophil chemotaxis; elevation of cytosolic calcium ion concentration; positive regulation of leukocyte chemotaxis; immune response; hemopoiesis; response to lipopolysaccharide; inflammatory response; chemotaxis; regulation of cell proliferation
Research Articles on rGRO g/CINC-2a
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Product Notes
The rGRO g/CINC-2a cxcl3 (Catalog #AAA144808) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: RELRCQCLKT LPRVDFENIQ SLTVTPPGPH CTQTEVIATL KDGQEVCLNP QAPRLQKIIQ KLLKSDKSS. It is sometimes possible for the material contained within the vial of "GRO-gamma, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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