Macrophage Migration Inhibitor Factor Recombinant Protein | rMIF recombinant protein
Recombinant Rat Macrophage Migration Inhibitor Factor
Sterile Filtered White lyophilized (freeze-dried) powder.
Introduction: The cytokine Macrophage migration inhibitory factor (MIF) has been identified to be secreted by the pituitary gland and the monocyte/macrophage and to play an important role in endotoxic shock. MIF has the unique property of being released from macrophages and T cells in response to physiological concentrations of glucocorticoids. The secretion of MIF is tightly regulated and decreases at high, anti-inflammatory steroid concentration.
NCBI and Uniprot Product Information
NCBI Description
inhibits random migration of macrophages and is involved in the pathogenesis of several inflammatory diseases [RGD, Feb 2006]
Uniprot Description
MIF: a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. Also acts as a phenylpyruvate tautomerase.
Protein type: Amino Acid Metabolism - tyrosine; EC 5.3.2.1; Isomerase; Apoptosis; Amino Acid Metabolism - phenylalanine; EC 5.3.3.12; Cytokine; Cell development/differentiation
Cellular Component: nucleoplasm; extracellular space; cell surface; cytoplasm; extracellular region; intracellular; nucleus; myelin sheath; vesicle
Molecular Function: phenylpyruvate tautomerase activity; hematopoietin/interferon-class (D200-domain) cytokine receptor binding; protein complex binding; cytokine activity; dopachrome isomerase activity; chemoattractant activity; receptor binding
Biological Process: skin development; positive regulation of immune response; wound healing; DNA damage response, signal transduction by p53 class mediator; metabolic process; response to menaquinone; positive regulation of potassium ion transport; response to glucocorticoid stimulus; drinking behavior; response to hormone stimulus; positive regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of cellular protein metabolic process; response to lipopolysaccharide; positive regulation of smooth muscle cell migration; prostaglandin biosynthetic process; response to estradiol stimulus; response to insulin stimulus; negative regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of glucose import; positive regulation of MAP kinase activity; negative regulation of myeloid cell apoptosis; response to vitamin E; positive regulation of fibroblast proliferation; cell surface receptor linked signal transduction; negative regulation of mature B cell apoptosis; positive chemotaxis; hair follicle development; positive regulation of acute inflammatory response; positive regulation of B cell proliferation; inflammatory response; aging; response to drug; positive regulation of axon regeneration; response to inorganic substance; carboxylic acid metabolic process; cell aging; positive regulation of peptidyl-serine phosphorylation; brain renin-angiotensin system; regulation of cell proliferation; cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; response to heat; response to mechanical stimulus; positive regulation of glycolysis; innate immune response; spermatogenesis; brain development; positive regulation of protein amino acid phosphorylation; response to progesterone stimulus; positive regulation of phosphorylation; positive regulation of cytokine secretion; negative regulation of apoptosis
Research Articles on rMIF
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Product Notes
The rMIF mif (Catalog #AAA144617) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: MPMFIVNTNV PRASVPEGFL SELTQQLAQA TGKPAQYIAV HVVPDQLMTF SGTSDPCALC SLHSIGKIGG AQNRNYSKLL CGLLSDRLHI SPDRVYINYY DMNAANVGWN GSTFA. It is sometimes possible for the material contained within the vial of "Macrophage Migration Inhibitor Factor, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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