DIRAS family Recombinant Protein | DIRAS1 recombinant protein

Recombinant Human DIRAS family, GTP-binding RAS-like 1

Cat. Num. AAA144315

• Gene Names: DIRAS1; RIG; GBTS1; Di-Ras1
• Purity: Greater than 95% as determined by SDS-PAGE.
• Synonyms: DIRAS family; Recombinant Human DIRAS family; GTP-binding RAS-like 1; DIRAS1 Human; GTP-binding RAS-like 1 Human Recombinant; GTP-binding protein Di-Ras1; Distinct subgroup of the Ras family member 1; Ras-related inhibitor of cell growth; Rig; Small GTP-binding tumor suppressor 1; DIRAS1; GBTS1; Di-Ras1; FLJ42681; DIRAS1 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 95% as determined by SDS-PAGE.
• Form/Format: DIRAS1 Human solution (1mg/ml) containing 20mM Tris-HCl buffer(pH 8.0) containing 20% glycerol, 1mM DTT, 0.1M NaCl and 1mM EDTA.; Sterile filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MPEQSNDYRV VVFGAGGVGK SSLVLRFVKG TFRDTYIPTI EDTYRQVISC DKSVCTLQIT DTTGSHQFPA MQRLSISKGH AFILVFSVTS KQSLEELGPI YKLIVQIKGS VEDIPVMLVG KCDETQREV DTREAQAVAQ EWKCAFMETS AKMNYNVKEL FQELLTLETR RNMSLNIDGK RSGKQKRTDR KGKC
• Sequence Length: 198

• Preparation and Storage: DIRAS1 Human although stable at 4 degree C for 1 week, should be stored desiccated below -18 degree C. Please prevent freeze thaw cycles.

Related Product Information for DIRAS1 recombinant protein

Description: DIRAS1 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 215 amino acids (1-195a.a.) and having a molecular mass of 24.1 kDa. DIRAS1 protein is fused to a 20 amino acid His tag at N-terminus and is purified by standard chromatography.

Introduction: DIRAS1 is a member of a distinct branch of the functionally diverse Ras superfamily of monomeric GTPases. DIRAS1 demonstrates low GTPase activity and exists mainly in the GTP-bound form. Ras proteins operate as binary molecular switches that control intracellular signaling networks. Ras-regulated signal pathways regulate such processes as actin cytoskeletal integrity, proliferation, differentiation, cell adhesion, apoptosis, and cell migration. Ras and ras-related proteins are frequently deregulated in cancers, leading to increased invasion and metastasis, and decreased apoptosis.

Product Categories/Family for DIRAS1 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; Member RAS Oncogene Family

NCBI and Uniprot Product Information

• NCBI GI #: 21553323
• NCBI GeneID: 148252
• NCBI Accession #: NP_660156.1
• NCBI GenBank Nucleotide #: NM_145173.3
• UniProt Accession #: O95057
• Molecular Weight: 22,329 Da
• NCBI Official Full Name: GTP-binding protein Di-Ras1
• NCBI Official Synonym Full Names: DIRAS family, GTP-binding RAS-like 1
• NCBI Official Symbol: DIRAS1
• NCBI Official Synonym Symbols: RIG; GBTS1; Di-Ras1
• NCBI Protein Information: GTP-binding protein Di-Ras1; distinct subgroup of the Ras family member 1; ras-related inhibitor of cell growth; small GTP-binding tumor suppressor 1
• UniProt Protein Name: GTP-binding protein Di-Ras1
• Protein Family: GTP-binding protein
• UniProt Gene Name: DIRAS1
• UniProt Synonym Gene Names: GBTS1; RIG; Rig
• UniProt Entry Name: DIRA1_HUMAN

NCBI Description

DIRAS1 belongs to a distinct branch of the functionally diverse Ras (see HRAS; MIM 190020) superfamily of monomeric GTPases.[supplied by OMIM, Apr 2004]

Uniprot Description

DIRAS1: Displays low GTPase activity and exist predominantly in the GTP-bound form. Belongs to the small GTPase superfamily. Di-Ras family.

Protein type: G protein, monomeric, di-Ras; G protein; G protein, monomeric

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: plasma membrane

Molecular Function: GTPase activity; GTP binding; mitogen-activated protein kinase binding

Biological Process: positive regulation of MAP kinase activity; metabolic process; small GTPase mediated signal transduction