Disulfide Isomerase A6 Recombinant Protein | PDIA6 recombinant protein

Recombinant Human Protein Disulfide Isomerase A6

Cat. Num. AAA144267

• Gene Names: PDIA6; P5; ERP5; TXNDC7
• Purity: Greater than 90.0% as determined by SDS-PAGE.
• Synonyms: Disulfide Isomerase A6; Recombinant Human Protein Disulfide Isomerase A6; PDIA6 Human; Protein Disulfide Isomerase A6 Human Recombinant; Protein disulfide-isomerase A6; Endoplasmic reticulum protein 5; ER protein 5; ERp5; Protein disulfide isomerase P5; Thioredoxin domain-containing protein 7; PDIA6; ERP5; P5; TXNDC7; PDIA6 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 90.0% as determined by SDS-PAGE.
• Form/Format: The PDIA6 solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 10% glycerol, 2mM DTT and 50mM NaCl.; Sterile Filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MLYSSSDDVI ELTPSNFNRE VIQSDSLWLV EFYAPWCGHC QRLTPEWKKA ATALKDVVKV GAVDADKHHS LGGQYGVQGF PTIKIFGSNK NRPEDYQGGR TGEAIVDAAL SALRQLVKDR LGGRSGGYSS GKQGRSDSSS KKDVIELTDD SFDKNVLDSE DVWMVEFYAP WCGHCKNLEP EWAAAASEVK EQTKGKVKLA AVDATVNQVL ASRYGIRGFP TIKIFQKGES PVDYDGGRTR SDIVSRALDL FSDNAPPPEL LEIINEDIAK RTCEEHQLCV VAVLPHILDT GAAGRNSYLE VLLKLADKYK KKMWGWLWTE AGAQSELETA LGIGGFGYPA MAAINARKMK FALLKGSFSE QGINEFLREL SFGRGSTAPV GGGAFPTIVE REPWDGRDGE LPVEDDIDLS DVELDDLGKD EL
• Sequence Length: 492

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Related Product Information for PDIA6 recombinant protein

Description: PDIA6 Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 442 amino acids (20-440 a.a.) and having a molecular mass of 48.5kDa. The PDIA6 is purified by proprietary chromatographic techniques.

Introduction: PDIA6 belongs to the protein disulfide isomerase family (PDI). PDIA6 is an enzyme in the endoplasmic reticulum in eukaryotes or periplasmic space of prokaryotes which catalyzes the formation and breakage of disulfide bonds between cysteine residues within proteins as they fold. PDIA6 functions as a chaperone that inhibits aggregation of misfolded proteins. PDIA6, also has a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin.

Product Categories/Family for PDIA6 recombinant protein

Enzymes; Isomerase

NCBI and Uniprot Product Information

• NCBI GI #: 544186032
• NCBI GeneID: 10130
• NCBI Accession #: NP_001269633.1
• NCBI GenBank Nucleotide #: NM_001282704.1
• UniProt Accession #: Q15084; Q53RC7; Q6ZSH5; Q99778; B3KY95; B5MCQ5; B7Z254; B7Z4M8; F8WA83
• Molecular Weight: 53,261 Da
• NCBI Official Full Name: protein disulfide-isomerase A6 isoform a
• NCBI Official Synonym Full Names: protein disulfide isomerase family A, member 6
• NCBI Official Symbol: PDIA6
• NCBI Official Synonym Symbols: P5; ERP5; TXNDC7
• NCBI Protein Information: protein disulfide-isomerase A6; ER protein 5; endoplasmic reticulum protein 5; protein disulfide isomerase P5; protein disulfide isomerase-associated 6; protein disulfide isomerase-related protein; thioredoxin domain containing 7 (protein disulfide isomerase); thioredoxin domain-containing protein 7
• UniProt Protein Name: Protein disulfide-isomerase A6
• Protein Family: Protein disulfide-isomerase
• UniProt Gene Name: PDIA6
• UniProt Synonym Gene Names: ERP5; P5; TXNDC7; ER protein 5; ERp5
• UniProt Entry Name: PDIA6_HUMAN

NCBI Description

Protein disulfide isomerases (EC 5.3.4.1), such as PDIA6, are endoplasmic reticulum (ER) resident proteins that catalyze formation, reduction, and isomerization of disulfide bonds in proteins and are thought to play a role in folding of disulfide-bonded proteins (Hayano and Kikuchi, 1995 [PubMed 7590364]).[supplied by OMIM, Mar 2008]

Uniprot Description

PDIA6: May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin. Belongs to the protein disulfide isomerase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Isomerase; EC 5.3.4.1

Chromosomal Location of Human Ortholog: 2p25.1

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum lumen; endoplasmic reticulum; ER-Golgi intermediate compartment; melanosome; plasma membrane

Molecular Function: protein binding; protein disulfide isomerase activity

Biological Process: unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; protein folding; cell redox homeostasis; unfolded protein response; apoptotic cell clearance