N-Ethylmaleimide-Sensitive Factor Attachment Protein, Alpha Recombinant Protein | NAPA recombinant protein
Recombinant Human N-Ethylmaleimide-Sensitive Factor Attachment Protein, Alpha
Sterile Filtered colorless solution.
Introduction: NAPA is part of the SNAP (Soluble NSF Attachment Protein) family. SNAPs, acting together with SNAREs (SNAP receptors) and the N-ethylmaleimide-sensitive fusion protein (NSF), are necessary for the fusion of transport vesicles to their objective membranes in synaptic transmission, intra-Golgi transport, endosome-to-endosome fusion and transcytotic vesicles-to-plasma membrane transport. NAPA is in charge of the binding of NSF and therefore the formation of a 20S fusion particle.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the soluble NSF attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. The encoded protein plays a role in the completion of membrane fusion by mediating the interaction of N-ethylmaleimide-sensitive factor (NSF) with the vesicle-associated and membrane-associated SNAP receptor (SNARE) complex, and stimulating the ATPase activity of NSF. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jun 2011]
Uniprot Description
SNAP-alpha: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. Belongs to the SNAP family.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 19q13.33
Cellular Component: SNARE complex; membrane; vacuolar membrane; cytosol
Molecular Function: protein binding; syntaxin binding; soluble NSF attachment protein activity
Biological Process: neuron differentiation; synaptic transmission, glutamatergic; intracellular protein transport; intra-Golgi vesicle-mediated transport; apical protein localization; brain development; post-Golgi vesicle-mediated transport
Research Articles on NAPA
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Product Notes
The NAPA napa (Catalog #AAA144145) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: MGSSHHH HHH SSGLVPRGSH MDNSGKEAEA MALLAEAERK VKNSQSFFSG LFGGSSKIEE ACEIYARAAN MFKMAKNWSA AGNAFCQAAQ LHLQLQSKHD AATCFVDAGN AFKKADPQEA INCLMRAIEI YTDMGRFTIA AKHHISIAEI YETELVDIEK AIAHYEQSAD YYKGEESNSS ANKCLLKVAG YAALLEQYQK AIDIYEQVGT NAMDSPLLKY SAKDYFFKAA LCHFCIDMLN AKLAVQKYEE LFPAFSDSRE CKLMKKLLEA HEEQNVDSYT ESVKEYDSIS RLDQWLTTML LRIKKTIQGD EEDLR. It is sometimes possible for the material contained within the vial of "N-Ethylmaleimide-Sensitive Factor Attachment Protein, Alpha, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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